DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cam and CAPN9

DIOPT Version :9

Sequence 1:	NP_001246276.1	Gene:	Cam / 36329	FlyBaseID:	FBgn0000253	Length:	149	Species:	Drosophila melanogaster
Sequence 2:	XP_011542319.1	Gene:	CAPN9 / 10753	HGNCID:	1486	Length:	721	Species:	Homo sapiens

Alignment Length:	155	Identity:	39/155 - (25%)
Similarity:	76/155 - (49%)	Gaps:	24/155 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DQLTEEQIAEFKEAFSLFDK--DGDGTITTKELGTVMRSLGQNPTEAEL--------QDMINEVD 57
            ||.|||: ..|:   :||::  ..|..:|.:||..|:.::.|...:.:.        :::|:.:|
Human   514 DQETEEE-QRFR---ALFEQVAGEDMEVTAEELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMD 574

  Fly    58 ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEV 122
            ..|||.::|.||....       |..::....|..||.|.:|.:|..|||..:...|.:|:...:
Human   575 TSGNGKLEFDEFKVFW-------DKLKQWINLFLRFDADKSGTMSTYELRTALKAAGFQLSSHLL 632

  Fly   123 DEMI-READIDGDGQVNYEEFVTMM 146
            ..:: |.|  |.:.|:::::|:..:
Human   633 QLIVLRYA--DEELQLDFDDFLNCL 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cam	NP_001246276.1	PTZ00184	1..149	CDD:185504	39/155 (25%)
CAPN9	XP_011542319.1	Peptidase_C2	43..335	CDD:279042
		Calpain_III	349..491	CDD:279416
		PTZ00184	514..657	CDD:185504	39/155 (25%)
		EFh	566..621	CDD:238008	18/61 (30%)
		EFh	600..652	CDD:298682	15/53 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910