DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha36-2 and VMA8

DIOPT Version :9

Sequence 1:	NP_610753.1	Gene:	Vha36-2 / 36328	FlyBaseID:	FBgn0033706	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_010863.1	Gene:	VMA8 / 856659	SGDID:	S000000777	Length:	256	Species:	Saccharomyces cerevisiae

Alignment Length:	248	Identity:	80/248 - (32%)
Similarity:	132/248 - (53%)	Gaps:	18/248 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IFPSRANSVIMKQRVLAARRGVGLLKRKRDAIDMKLRELRRIRFDQDMHGDEAMRNAIFSMAKAN 73
            :||:|....:||.::..|.:|..|||||.:|:..:.|::.:...|........|:.|.||:|:.:
Yeast     8 VFPTRMTLGLMKTKLKGANQGYSLLKRKSEALTKRFRDITKRIDDAKQKMGRVMQTAAFSLAEVS 72

  Fly    74 -LLGADFKPQMVSRSHVATVSLRRTEIKIVGVKLNTLE--LETKGVGAFPLAGLSCGGMQVSRIR 135
             ..|.:...|:......|...:|..:..:.||.|:..|  ::.: :..|.|.||..||.||.|.:
Yeast    73 YATGENIGYQVQESVSTARFKVRARQENVSGVYLSQFESYIDPE-INDFRLTGLGRGGQQVQRAK 136

  Fly   136 DSYTKALKALVEFASLEYQVRMLEAASLQTNMRVNALEHVVIPILQNTYNYICGELEEFEREDFY 200
            :.|::|::.|||.|||:....:|:.....||.||||:|||:||..:||..||..||:|.:||:||
Yeast   137 EIYSRAVETLVELASLQTAFIILDEVIKVTNRRVNAIEHVIIPRTENTIAYINSELDELDREEFY 201

  Fly   201 RLKRSQAKQLEAKMAFTELIKTKNMTDEELETYIKRNINQTRPPAADTPFDQE 253
            |||:.|.|:             :|.| .:|:..:|...::....|::...|:|
Yeast   202 RLKKVQEKK-------------QNET-AKLDAEMKLKRDRAEQDASEVAADEE 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha36-2	NP_610753.1	ATP-synt_D	18..206	CDD:280060	68/190 (36%)
		PEHE	<253..>294	CDD:291924	1/1 (100%)
		DUF4628	<281..>373	CDD:292069
VMA8	NP_010863.1	V_ATPase_subD	5..213	CDD:129409	73/218 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346431
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1394
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S324
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101069
Panther	1	1.100	-	-	O	PTHR11671
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.650