DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf149 and RNF149

DIOPT Version :9

Sequence 1:	XP_017452282.1	Gene:	Rnf149 / 363222	RGDID:	1308460	Length:	394	Species:	Rattus norvegicus
Sequence 2:	XP_005263977.1	Gene:	RNF149 / 284996	HGNCID:	23137	Length:	428	Species:	Homo sapiens

Alignment Length:	388	Identity:	301/388 - (77%)
Similarity:	329/388 - (84%)	Gaps:	8/388 - (2%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MAARRRPAAGVGARD--ALAVLALALCAPGVGGGALEWYSATVSIEYVDPQSNLTVWSVTESGRF 63
            ||.|||.|: ||||.  |||:||||||.||..|.||||:||.|:|||||||:|||||||:|||||
Human     1 MAWRRREAS-VGARGVLALALLALALCVPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSESGRF 64

  Rat    64 GDSSLREERQGLVGVPRAP-ADAEGCAPDTRFVA--PGALGNAPWVALVARGGCTFKDKVLAAAR 125
            ||||.:|...||||||.|| .|.|||||||||..  ||..|.|||||||||||||||||||.|||
Human    65 GDSSPKEGAHGLVGVPWAPGGDLEGCAPDTRFFVPEPGGRGAAPWVALVARGGCTFKDKVLVAAR 129

  Rat   126 RNASAVVVYNQERYGNATEPMSHAGTGSIVVIMISYPKGREISDLVQKGIPVKMRIEIGTRHMQE 190
            |||||||:||:|||||.|.||||||||:||||||||||||||.:||||||||.|.|.:||||:||
Human   130 RNASAVVLYNEERYGNITLPMSHAGTGNIVVIMISYPKGREILELVQKGIPVTMTIGVGTRHVQE 194

  Rat   191 FISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQFGSQNHRKETKKVIGQLPLHTVKHGE 255
            |||||||||||||||||||||||||||||||||||||||.|||:||||||||||||.||||||||
Human   195 FISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQIGSQSHRKETKKVIGQLLLHTVKHGE 259

  Rat   256 KGIDVDAENCAVCIENFKVKDVIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGDPE 320
            |||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||:|.
Human   260 KGIDVDAENCAVCIENFKVKDIIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGEPG 324

  Rat   321 DAQDLPIPEAAPGSVSVGNLSVTVQDEERS-ESNLPSSSSSEFGPH-RPCLKEDAEEDTALLG 381
            |.|::|.||:.||.....|||:.:.|::.| :|:.||:|.:|..|. .|..|.||.|:|||||
Human   325 DVQEMPAPESPPGRDPAANLSLALPDDDGSDDSSPPSASPAESEPQCDPSFKGDAGENTALLG 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf149	XP_017452282.1	PA_GRAIL_like	45..181	CDD:239037	111/138 (80%)
		UPF0233	<200..>220	CDD:299753	19/19 (100%)
		zf-RING_2	263..306	CDD:290367	41/42 (98%)
RNF149	XP_005263977.1	PA_GRAIL_like	43..185	CDD:239037	113/141 (80%)
		UPF0233	<204..>235	CDD:299753	30/30 (100%)
		zf-RING_2	267..310	CDD:290367	41/42 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696362
Domainoid	1	1.000	102	1.000	Domainoid score	I42252
eggNOG	1	0.900	-	-		E1_KOG4628
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18337
Inparanoid	1	1.050	600	1.000	Inparanoid score	I10184
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37272
OrthoDB	1	1.010	-	-		D111470at9347
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto144274
orthoMCL	1	0.900	-	-		OOG6_119631
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.270