Protein Alignment CG8858 and ECM29

DIOPT Version :9

• Sequence 1: NP_610746.1
• Gene: CG8858 / 36319
• FlyBaseID: FBgn0033698
• Length: 1890
• Species: Drosophila melanogaster
• Sequence 2: NP_011833.1
• Gene: ECM29 / 856355
• SGDID: S000001022
• Length: 1868
• Species: Saccharomyces cerevisiae
• Alignment Length: 2098
• Identity: 479/2098 - (22%)
• Similarity: 826/2098 - (39%)
• Gaps: 467/2098 - (22%)

  Fly     8 EIELLERVLLRLGNADSDEKLEAAVGKFLTPVILKMNSPHNVVRTKVVEVLTHIKRRLSSRGHVQ 72
            |.:|:|:..|||..|||.:|.|..:..||.|::||:.|||..|||.|...|.::..|:::...||
Yeast    10 EKQLVEKAELRLAIADSPQKFETNLQTFLPPLLLKLASPHASVRTAVFSALKNLISRINTLPQVQ 74

  Fly    73 IPVEALLDQ-----YAAQDSSTFLKNFAIIFITMGFPRLALEQQTALASKVVGCEDKLE-SYQDK 131
            :||.||:.|     .|||..||.::.::::..:.|..||:|:.:..|...||.....|. :...:
Yeast    75 LPVRALIVQAKEPNLAAQQDSTNVRLYSLLLASKGIDRLSLQDRQQLLPLVVSNISCLTGTVAAR 139

  Fly   132 LFALLLPVLSDMKIPDDPTQRSKLLDLQDKPAICANFLALLQD------------VLLLPYGITQ 184
            :|.:||.::.:...|.:.:...:..         ..||.|..|            .||:|....|
Yeast   140 MFHILLKLILEWVAPQESSHEQEEF---------VQFLQLDNDGFSFLMRQFTRFFLLVPSKQVQ 195

  Fly   185 EQDVP-------PGLSPYS---FTRIIAYNWRAEELEKVKKGIVRFLCASVFSDLQIFVPLVVAS 239
            ....|       ||||...   ||......:..|:|.|.||.|.:|:|..:
Yeast   196 VSQQPLSRGYTCPGLSLTDVAFFTYDAGVTFNKEQLNKFKKAIFQFVCRGM-------------- 246

  Fly   240 ADTRFSVATPAITELSK-LCTM-------------------LDFSNPAVTAPLYTLFAGNQSKIT 284
            |.|:....:|.:.||.: ||.:                   :.:.|......|.||:.||    |
Yeast   247 AATQTIEQSPRMIELMEFLCVVSTDSTNLSDDAAQFMKRFPMPYENEEFITFLQTLYIGN----T 307

  Fly   285 DRQTRPCCARVRQKLLQYLIKCRGKSINVTKGLQVTFDGFFGTNTNQ-KCKVLALQFMELLLRDG 348
            .....|..|.:::|:|..|.:   .....||...::.....|.:::: |.:.|.|.|:
Yeast   308 ANGRPPVKAILQEKILSILNR---SHFATTKAECISLICSIGLHSSEYKLRSLTLSFI------- 362

  Fly   349 PRELVSKVSKVILTGITKIIGRDSNEPN--DVQNAAYSALAQ--HARSFPQ-------------- 395
              ..|:|::       .|.:...|:.|:  |......|.:..  ||..:|:
Yeast   363 --RHVAKLN-------YKNLNPASSSPSSTDFSTCIVSLIRNNLHAEGWPKLQLGPQTPAFNTAI 418

  Fly   396 -----------DV-SQDLKLV--LGY----FNNLASCAPELHSSIREALVSMAPAFAWKTKEKSD 442
                       |: .:|.:||  |.|    |.:|.:..|:..|||:|:|:|:....:...::...
Yeast   419 LQRQLQYETLGDILKRDFELVSDLSYIEFLFESLKNDLPQFRSSIQESLLSLVGHLSILPQQSKL 483

  Fly   443 AMEVDKNVDSSSVKLDGQQHLLLAMLLDN--AESKVQIVQNVTSVFLTSCYPEYYAPARYLLLLI 505
            .:   ||:...::.:|.||.      .||  |.:.:..::.|:..|..:.:|.:...||..
Yeast   484 KL---KNLLRKNLSIDEQQR------EDNNDAVNSIMALKFVSIKFTNAAFPFHDPEARLF---- 535

  Fly   506 AGERNSLRENVTTYLYGTSKKDHINYSMLSSIDHSKN-------RISSESI--------SDF--N 553
                         .::||.:.:..:.     |:.|..       |:::.||        ||.  :
Yeast   536 -------------NIWGTVRTNRFDI-----IEESFKGLQPFWFRVNNASINTSATVKTSDLLGS 582

  Fly   554 HLSLEQRRVMLPSF----QVMMSHVHEMAEKRLKK--NTA------CV----VVGRTKLPYSLEV 602
            |||    ....|.|    ||::..:...|....:|  |.|      |:    :.|:..:....|.
Yeast   583 HLS----ETEFPPFREFLQVLIDQLDSEAASITRKSLNNAVRFSKQCLISNAIYGKKTMVIQDED 643

  Fly   603 YEELLDYLRLCLWYSAGVVAAPGDEKYTHELREYITLHYEDTEDNALHQYAQFVQRSVEAKRSES 667
            :...:|            .|...|:.....:.|.:    :...|:...:|...:.....|..|:.
Yeast   644 WSVRID------------KALELDDTVVSRVNEMV----QGMNDDIFIRYLTLLSNEFTATNSKG 692

  Fly   668 NLICLYDLLNAAPELFAAKQLHLLEPLGNTLKDVSETMRINVAQVYGILWAFGLSDEKFDEEVGE 732
            ..|.::...:   .:|.:..|.||..:.|   :|...:.|.|..:|.:
Yeast   693 EQIAIFPYQD---PIFGSVLLTLLNFVSN---NVLRRLEILVPDLYHL----------------- 734

  Fly   733 CLNSLTQKTLEHKHGWLLVVGHTFNRKIAMLKQENKTKDFAAWPQFVNAVKIISKCLCESQWLLV 797
                                       :.|..|.....|.|.....:.   |||..:.:
Yeast   735 ---------------------------VIMKFQSLSDNDLAVCATIIG---IISTAIAD------ 763

  Fly   798 SAAVKCISMIGKAVEIPNVPV-EIQVPS---KDGDDDDEE---------MTEY-----TSIDSST 844
            |..||.|:.|.::..:....| ...||.   ||..:..|.         :|.:     |:.|...
Yeast   764 STHVKRITKIAQSQTMAETYVASYVVPRLYLKDQTNHIESDSILNLLNILTTHLSHPGTNKDMIL 828

  Fly   845 KLVIFGVVFQLLRSSSARQ--------------KIRED--SARCLGYLAIGDGEHFTKRNLDKFL 893
            |||.....|.||...||::              |:..|  :.:...||::...:........:.|
Yeast   829 KLVCQVTKFGLLLQVSAQERKDFLKKVMDTIQDKLINDVTAIQTWSYLSLYSTDLENSSLFQEKL 893

  Fly   894 TLTKIQKDAALNIAISEAIVNTLCGYDVNKGQPDEKFVNKHCNDDDFD------QFLNSLIRLVT 952
            ..|.:.|......::.|::       .|..|:...|::.|..:..:|:      :|..:.:..:.
Yeast   894 LETNVSKQNDFLFSVGESL-------SVVAGKWSSKYLIKQIDIPNFNVEIMQQKFPATNVTTIL 951

  Fly   953 D--------PNPHSRQAISVWLLAVVKHCSQRPAVLAKKELLQFAFTELLSDDSEFVQDVASRGL 1009
            |        ..|..|:|..:|||:.:::....|.|.:|...:...|...|:|..||:||.|:|||
Yeast   952 DEIFSGCDSTKPSLRKASCIWLLSYIQYLGHLPEVSSKCNDIHLRFMRFLADRDEFIQDSAARGL 1016

  Fly  1010 GLVYSISDSGSQSDLANSLL---DQLIGGKRKVN------QVTADTELFAEGMLGKTPTG-GNIT 1064
            .|||.|..|..:..:...||   .:...|....:      .|:.:||||..|:|.   || |:|:
Yeast  1017 SLVYEIGGSDLKESMVKGLLKSFTESTAGSASTSATGISGSVSEETELFEPGVLN---TGDGSIS 1078

  Fly  1065 TYKELCSLASDLNQPDMIYQFMQLANHNATWTSKLGAAFGLKTLSAESRQKMEPYL-------GK 1122
            |||::.:|||::..|.::|:||.||..:|.|:|:.|.||||..:.  |:..:|..|       .|
Yeast  1079 TYKDILNLASEVGDPALVYKFMSLAKSSALWSSRKGIAFGLGAIM--SKSSLEELLLKDQQTAKK 1141

  Fly  1123 IIPRLYRYKYDPTPKIQNSMISIWDTIVTDSKEVTERYYWEILRELLDNLTCKEWRVRIACCLAV 1187
            :||:||||::||...:..||..||:|::.:|......|:.:||.|||..:..||||||.|...|:
Yeast  1142 LIPKLYRYRFDPFQAVSRSMTDIWNTLIPESSLTISLYFNDILDELLCGMANKEWRVREASTSAL 1206

  Fly  1188 RDLLNRPNGLKLRSEEPVRRALPDNSMEVDEVPEPELKELWFQLFRVMDDIHEGTRVAAHGTASF 1252
            ..|:                    .|...::..|..|| :|...||.||||.:..|.......:.
Yeast  1207 LQLI--------------------QSQPQEKFSEKMLK-IWTMAFRTMDDIKDSVREVGTKFTTV 1250

  Fly  1253 LGKLCVIASSSDHGKSGT---AVASSILPFLL-ETGVGHKVPEIRRVSIKTISDMIDSSGSLIAP 1313
            |.|:...:...:.|.:.|   .:..:|||||. ..|:.....|:|..::.|:.|::..|...|.|
Yeast  1251 LAKILARSIDVEKGVNPTKSKEILDNILPFLWGPHGLNSDAEEVRNFALTTLIDLVKHSPGAIKP 1315

  Fly  1314 HLATLIPCLLRATGELENTKLSYVSTRLGADNEAQEAVDTLRAEAAKSLHTMETIGKCVRYIDYS 1378
            ....||...:.....:|...::|::......|.....:||.|.....:....:||.|.:...|..
Yeast  1316 FTPKLIYDFITLFSSIEPQVINYLALNAANYNIDANVIDTQRKNGVTNSPLFQTIEKLINNSDDC 1380

  Fly  1379 VLEKMTPEVLELMKGSVNLGTKIGCAHFVCLISIRLGKEMTPLVGKYIRACFVGIKNRNATVRKY 1443
            ::|::...|::..:.||.|.:|:..:..:.::..|...||.|..||.::.|....::||.:|...
Yeast  1381 MMEEIINVVIKASRKSVGLPSKVASSLVIIILVKRYSIEMKPYSGKLLKVCLTMFEDRNESVNIA 1445

  Fly  1444 NASAIGHLLGL-AKEQSIK---SLFTKLEELYAEQPGNRSIALTIQSINKRHHELLKDYMDSMLP 1504
            .|.::|:|..: |.::.||   .|.||..|..:.:...:.:...|.||.........:.....:|
Yeast  1446 FAISMGYLFKVSALDKCIKYSEKLITKYFEPTSTENNKKVVGTAIDSILNYAKSEFDNVASVFMP 1510

  Fly  1505 LIFFAMHEEPNEETKANVELWKDLWHDVSPGDAG-IRLNLNVIIPKLESSLTDASWSRKAQAANA 1568
            |||.|.    |:|.|....|:..:|.:.|...|| ::|.|..|:..|..::....:|.:...|.:
Yeast  1511 LIFIAC----NDEDKDLETLYNKIWTEASSSGAGTVKLYLPEILNVLCVNIKSNDFSIRKTCAKS 1571

  Fly  1569 IQTIATRLSSSLDEPDRLRLIKLLLSGLQGRTFEGKERLLQALAALTKGLDR------------N 1621
            :..:...::.|:..|..::|..:....|.||:::|||.::.||.:||:...:            |
Yeast  1572 VIQLCGGINDSIPYPQIVKLFDISREALSGRSWDGKEHIVAALVSLTEKFSQTVADNNDLQESIN 1636

  Fly  1622 HQICSSIIDAAMREARKREPVYRTMALASLGEILDQLEADRFEEVYNMSWNLLEK-KE----LRK 1681
            |.:.:.:...:|:..:|..|:|     |....:..|.|...|         |:|| ||    |..
Yeast  1637 HVMYTEVSRKSMKYVKKILPLY-----ARYINVNPQEETITF---------LIEKAKEMIRLLGS 1687

  Fly  1682 ESDDEDEPNTSQELSADERNKRAQTLNRLKEVVWETLGKSWPRHSIETQHRYQLFFAENCTSILA 1746
            ||||.:   .|.:.::||     .|:.|:|... |...|| .:.:||.: .|.:...:....|..
Yeast  1688 ESDDSE---GSIKQTSDE-----STIKRIKPNT-EITQKS-SKENIENE-EYVINLLKVSVDICN 1741

  Fly  1747 ESTRPVQVSLLAALTKYIERLHVFDESAQVPDLTQINQEKKIKTEETAPKTRE---AIVEKICTD 1808
            .|.....::||.         .:.||.|.:     .:.::.|.|..|.....|   :||.:..|
Yeast  1742 NSKSRYPMNLLE---------FIIDEIAYL-----FHNDRIIHTWRTQLAASEIGISIVGRFST- 1791

  Fly  1809 VLAAVALAAGVPHSG----------LKKEAL-NIVLMLIKRLSGSGNGNQQPLRLIKQSFESNLE 1862
                ::.|..:.:.|          ..||.: |:.|.:||    .|....|.:..::.:.|.||.
Yeast  1792 ----ISSADFIQNVGRLWDQTFPINCNKETIENVKLQMIK----FGGLIIQKIPSLQNNIEENLR 1848

  Fly  1863 KFQR-DSAPEIRCRIKDI 1879
            .... ||...|...:|:|
Yeast  1849 LLNSIDSTSRIELELKNI 1866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8858	NP_610746.1	Ecm29	20..504	CDD:289751	130/570 (23%)
		HEAT repeat	1164..1189	CDD:293787	13/24 (54%)
		HEAT repeat	1226..1259	CDD:293787	10/32 (31%)
		HEAT repeat	1275..1302	CDD:293787	9/27 (33%)
		HEAT repeat	1502..1535	CDD:293787	11/32 (34%)
		HEAT repeat	1545..1575	CDD:293787	4/29 (14%)
		HEAT repeat	1584..1613	CDD:293787	9/28 (32%)
		HEAT repeat	1624..1654	CDD:293787	5/29 (17%)
ECM29	NP_011833.1	Ecm29	14..537	CDD:404029	134/594 (23%)
		HEAT repeat	1507..1535	CDD:293787	10/31 (32%)
		HEAT repeat	1548..1578	CDD:293787	4/29 (14%)
		HEAT repeat	1587..1616	CDD:293787	9/28 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343124
Domainoid	1	1.000	272	1.000	Domainoid score	I277
eggNOG	1	0.900	-	-		E1_KOG0915
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	364	1.000	Inparanoid score	I376
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55665
OrthoFinder	1	1.000	-	-		FOG0003485
OrthoInspector	1	1.000	-	-		oto99431
orthoMCL	1	0.900	-	-		OOG6_103321
Panther	1	1.100	-	-	LDO	PTHR23346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R364
SonicParanoid	1	1.000	-	-		X2852
TreeFam	1	0.960	-	-
	14	13.790