DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8858 and ecpas

DIOPT Version :9

Sequence 1:NP_610746.1 Gene:CG8858 / 36319 FlyBaseID:FBgn0033698 Length:1890 Species:Drosophila melanogaster
Sequence 2:NP_001155958.1 Gene:ecpas / 563777 ZFINID:ZDB-GENE-061207-66 Length:1867 Species:Danio rerio


Alignment Length:2016 Identity:639/2016 - (31%)
Similarity:1017/2016 - (50%) Gaps:292/2016 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 EIELLERVLLRLGNADSDEKLEAAVGKFLTPVILKMNSPHNVVRTKVVEVLTHIKRRLSSRGHVQ 72
            |:..||||.||||:|::||:|:..:.|||.||:||::|....||.||:|:|.|:.:|:.||..:|
Zfish     6 ELNQLERVFLRLGHAETDEQLQDIISKFLPPVLLKLSSVQEGVRKKVMELLVHLNKRIKSRPKIQ 70

  Fly    73 IPVEALLDQYAAQDSSTFLKNFAIIFITMGFPRLALEQQTALA-SKVVGCEDKLESYQDKLFALL 136
            :|||.||.||....:::|:.||.||:|.||:|||.:.:|..|| :.:...|.|.:..||.|..||
Zfish    71 LPVETLLVQYQDPSAASFVTNFTIIYIKMGYPRLEVSKQCELAPTLLTAMEGKPQPQQDSLMHLL 135

  Fly   137 LPVLSDMKIPDDPTQRSKLLDLQDKPAICANFLALLQDVLLLPYGI------------------- 182
            :|.|..||.|.:|::.|..: |.::|......|..:.||||:|||.                   
Zfish   136 IPTLYHMKYPSEPSKASPFV-LTERPKTVHLLLEFMLDVLLMPYGFVLNEPPSRPAPSSPQGGSG 199

  Fly   183 ---TQEQDV---PPGLSPYSFTRIIA-YNWRAEELEKVKKGIVRFLCASVFSDLQIFVPLVVASA 240
               |..|.:   |||:|.|:..|:|. ..|..|:||:.|.|||:|:.|....:::..:.|||||:
Zfish   200 AGATATQGLPQPPPGMSVYAVKRVIGEAQWSPEQLEQCKLGIVKFIEAEQVPEVETVIHLVVASS 264

  Fly   241 DTRFSVATPAITELSKLCTMLDFSNPAVTAPLYTLFAGNQSKITDRQT-------RPCCARVRQK 298
            |||.||||.|..||....:::|::||.:...:|.::.|:....|...|       .|...||:.|
Zfish   265 DTRHSVATAADLELKSKQSIIDWNNPLIINRMYKVYLGDIPLKTKGATVKQELKHEPVSTRVKMK 329

  Fly   299 LLQYLIKCRGKSINVTKGLQVTFDGFFGTNTNQKCKVLALQFMELLLRDGPRELVSKVSKVILTG 363
            :|.:|::.|..:......:||.:||.||.|||.|...|.|||:..:....| :....:..::|.|
Zfish   330 ILPHLLRSRLAAECFPANIQVVYDGLFGANTNNKLLSLTLQFVHHICMVCP-DTNKPLGLMLLNG 393

  Fly   364 ITKIIGRDSNEPNDVQNAAYSALAQHARSFPQDVSQDLKLVLGYFNNLASCAPELHSSIREALVS 428
            :||:|.....:|. :...||||:.:.:...||..::|:.||..:|.::.....::..:|:|||..
Zfish   394 LTKLINEYKEDPK-LLCMAYSAVGKLSSRMPQLFTKDIALVQQFFESMCKEEADVRLAIQEALSM 457

  Fly   429 MAPAFAWKTKEKSDAMEVDKNVDSSSVKLDGQQHLLLAMLLDNAESKVQIVQNVTSVFLTSCYPE 493
            |..|:|              |:..:.:.|   ...|:|..:...|  || |:.|...|.::.:..
Zfish   458 MVAAYA--------------NLQGALLNL---MEALVAAYITKPE--VQ-VRQVAMKFASTVFAP 502

  Fly   494 YYAPARYLLLLIAGERNSLRENVTTYLYGTSKKDHINYSMLSSIDHSKNRISSESISDFNHLSLE 558
            .:..:|:||||.||:.   ||.|.    |.:::      .|.|:..:|.             ..|
Zfish   503 DHVASRFLLLLAAGDP---REEVA----GEAQR------ALRSLPSTKT-------------EKE 541

  Fly   559 QRRVMLPSFQVMMSHVHEMAEKRLKKNTACVVVGRTKLPYSLEVYEELLDYLRLCLWYSAGVVA- 622
            ..|.| |||..|:|::.|.|.:|| |..|..:||.:.||::...:.|::.|||:||.:|:|... 
Zfish   542 GSRPM-PSFPEMVSYIQEKAAQRL-KTPAKYIVGTSTLPFNPATFSEIVLYLRMCLAHSSGATPT 604

  Fly   623 ----------APGDEKYTHEL---REYITLHYEDTEDNALHQYAQFVQRSVEAKRSESNLICLYD 674
                      ||...:|...|   ...::...:..:.|.:|.|...:|:.:.|......:.||.:
Zfish   605 SQSLMDMQDDAPLIGRYVQSLLSNEASLSSATKGGDANPVHIYIDLLQQLLSAVGGIPVMYCLLE 669

  Fly   675 LLNAAPELFAAK---QLHLLEPLGNTLKDVSETMRINVAQVYGILWAFGLSDEKFDEEVGECLNS 736
            :::..||...||   ::..::.|.||.|   |.||...||:|.:     :.......|:...:.:
Zfish   670 VVSVCPEKLTAKFVDKIDWIKGLMNTNK---EDMRELAAQLYAV-----VVSTMSGNELRTAVQN 726

  Fly   737 LTQKTL-----EHKHGWLL----VVGHTFNRKIAMLKQENKTKDFAAWPQFVNAVKIISKCLCES 792
            |.:.|.     |.:||.:|    :||...|:|..::..|..:::..  .....|.|.|...|...
Zfish   727 LIKTTKDMHSPETQHGAILALGYMVGRYMNKKRNLMPSEATSREDE--ELIAMATKTIGSFLNSE 789

  Fly   793 QWLLVSAAVKCISMIGK--AVEIPNVPVEIQVPSKDGDDDDEEMTEYTSIDSSTKLVIFGVVFQL 855
            ..||..|||..:..||:  .:.||          .||             :..|||.:...:...
Zfish   790 SALLTIAAVTALGEIGRNSVLLIP----------ADG-------------NGFTKLSLVDNLLTR 831

  Fly   856 LRSSSARQKIREDSARCLGYLAIGDGEHFTKRNLDKFLTLTKIQKDAALNIAISEAIVNTLCG-- 918
            :.|.....|::|.:.:.||:|.:||||...::.:.:.|..:...|...|...:.||:.|...|  
Zfish   832 IPSGKETGKMKERAIQTLGFLPVGDGEFPHQKKVLQGLMDSVEAKQVELQFTVGEALTNAAVGSC 896

  Fly   919 ----YDVNKGQPDEKFVNKHC------NDDDFDQFLNSLI-RLVTDPNPHSRQAISVWLLAVVKH 972
                .||.....|:     :|      |:|.....|||:: :.:..||||.|||..:|||::||.
Zfish   897 SGAARDVWTCTEDQ-----YCPPENVKNNDIVPWVLNSVLSKYIPSPNPHVRQAACIWLLSLVKK 956

  Fly   973 CSQRPAVLAKKELLQFAFTELLSDDSEFVQDVASRGLGLVYSISDSGSQSDLANSLLDQLIGGKR 1037
            .|....:.:..:.:|.||..:|||..|..|||||:||||||.:.....|.:|.::|::.|:.|||
Zfish   957 LSHHKEIQSHLKEIQTAFISVLSDPDELSQDVASKGLGLVYELGGEQDQQELVSTLVETLMTGKR 1021

  Fly  1038 KVNQVTADTELFAEGMLGKTPTGGNITTYKELCSLASDLNQPDMIYQFMQLANHNATWTSKLGAA 1102
            ..:.|:.|||:|....|||.|.|..::||||||||||||||||::|:||.||||:|.|.|:.|||
Zfish  1022 AKHAVSEDTEVFQGEALGKAPDGQGLSTYKELCSLASDLNQPDLVYKFMNLANHHAMWNSRKGAA 1086

  Fly  1103 FGLKTLSAESRQKMEPYLGKIIPRLYRYKYDPTPKIQNSMISIWDTIVTDSKEVTERYYWEILRE 1167
            ||...::|::.:::.|:|.:::||||||::||...|:.:|.||||.:||| |.:.|:|:.|||::
Zfish  1087 FGFNIIAAKAGEQLAPFLPQLVPRLYRYQFDPNLAIRQAMTSIWDALVTD-KTIVEKYFKEILQD 1150

  Fly  1168 LLDNLTCKEWRVRIACCLAVRDLLNRPNGLKLRSEEPVRRALPDNSMEVDEVPEPELKELWFQLF 1232
            ::.|||...||||.:.|||:.||:                    ...:.||:.: .|.|:|..||
Zfish  1151 VISNLTSNMWRVRESSCLALNDLI--------------------RGRQADEIID-RLSEIWETLF 1194

  Fly  1233 RVMDDIHEGTRVAAHGTASFLGKLCVIASSSDHGKSGTAVASSILPFLLETGVGHKVPEIRRVSI 1297
            ||:|||.|..|.||..|...|.|:||....|. |.:.....:.:||.||:.|:...|.|:|.:||
Zfish  1195 RVLDDIKESVRKAADLTLKTLSKVCVRMCEST-GATAQRTVAVLLPTLLDKGIVSNVTEVRTLSI 1258

  Fly  1298 KTISDMIDSSGSLIAPHLATLIPCLLRATGELENTKLSYVSTRLGADNE-------AQEAVDTLR 1355
            :|:..:..|:||.:.||...|||.||.|...||...|:|:|.|.....:       .|.|:|..|
Zfish  1259 QTLVKISKSAGSRLKPHAPRLIPALLEALSVLEPQVLNYLSLRATEQEKDIHNFFLRQSAMDAAR 1323

  Fly  1356 AEAAKSLHTMETIGKCVRYIDYSVLEKMTPEVLELMKGSVNLGTKIGCAHFVCLISIRLGKEMTP 1420
            ..||||...||||..|::::|.|||.::.|::.:|:|..:.||||.|||..:..::::..:::||
Zfish  1324 LSAAKSSPMMETINMCLQHLDVSVLGELVPKLCDLLKSGIGLGTKGGCASVIVSLTVQCPQDLTP 1388

  Fly  1421 LVGKYIRACFVGIKNRNATVRKYNASAIGHLLGLAKEQSIKSLFTKLEELYAEQPG---NRSIAL 1482
            ..||.:.|...||.:|::.|:|..|.|:|||:..||:.|::.|..||...|.|:..   ..|..|
Zfish  1389 YSGKLMSALLNGINDRSSVVQKSFAFAVGHLVRTAKDSSVEKLLQKLNTWYLEKEEALYKSSCCL 1453

  Fly  1483 TIQSINKRHHELLKDYMDSMLPLIFFAMHEEPNEE--TKANVELWKDLWHDVSPGD-AGIRLNLN 1544
            .:.:|:....::||.:....|||.|..||:|..||  ..|...||.::|.:..||. .||||.:.
Zfish  1454 VVHAISHYSPDVLKAHAGVALPLAFLGMHQEAEEEKGESAEANLWSEVWQEHVPGSFGGIRLYMT 1518

  Fly  1545 VIIPKLESSLTDASWSRKAQAANAIQTIATRLSSSLDEPDRLRLIKLLLSGLQGRTFEGKERLLQ 1609
            .:|...:.:|...||..|||.|.|:.|||.:.:.||..|....::..||.||.|||:.|||.||:
Zfish  1519 ELIGITQRALQSQSWKMKAQGAAAMATIAKQQTGSLVAPHLGMVLTALLQGLAGRTWAGKEELLK 1583

  Fly  1610 ALAALTKGLDRNHQ-------ICSSIIDAAMREARKREPVYRTMALASLGEILDQLEADRFEEVY 1667
            |:.::........|       ..|.::|..::|.:|...||:..||.|..:||:..:.|||.||.
Zfish  1584 AVGSVVSKCSVELQKPAAGQPTVSEVLDLVLKECKKESLVYKMAALRSAADILESTQVDRFHEVA 1648

  Fly  1668 NMSWNLLEKKE------LRKESDDEDEPNTSQELSADERNKRAQTLNRLKEVV---WETLGKSWP 1723
            .:...|::|.:      .|.:.||:|:...::||         ||     ||:   :|||||:||
Zfish  1649 EIVLPLIKKNQPASASSPRHDDDDDDDDAKAREL---------QT-----EVLLCAYETLGKAWP 1699

  Fly  1724 RHSIETQHRYQLFFAENCTSILAE----STRPVQVSLLAALTKYIERLHVFDESAQVPDLTQINQ 1784
            : :|:||:::|   .|.| :::.|    ||..||:.:|.|:..:.:.|.:.|:.         :|
Zfish  1700 K-TIQTQNQFQ---NEVC-NLMCERLKLSTWRVQLGVLRAMKVFYQGLLLLDKE---------HQ 1750

  Fly  1785 EKKIKTEETAPKTREAIVEKICTDVLAAVALAAGV---PHSGLKKEALNIVLMLIKRLSGSGNGN 1846
            ...:.||         ::.:.||      |||:.:   .:|.::.:||.:|.:|:||:.|..:.:
Zfish  1751 NAAVLTE---------LLSETCT------ALASPLENKSYSSVRTDALAVVELLLKRIEGIDDLH 1800

  Fly  1847 QQPLRLI--------------------------KQSFESNLEKFQRDSAPEIRCRIKDIEDKLSK 1885
            .....|.                          :|..:.:|...:.||.|:::.:.:.:..|:..
Zfish  1801 FHKTNLCDHRKALFVCVSNVPESDQWHCLCERSRQQLQRSLGTMETDSRPDLKDKAQTMRRKIQA 1865

  Fly  1886 L 1886
            |
Zfish  1866 L 1866

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8858NP_610746.1 Ecm29 20..504 CDD:289751 168/517 (32%)
HEAT repeat 1164..1189 CDD:293787 12/24 (50%)
HEAT repeat 1226..1259 CDD:293787 17/32 (53%)
HEAT repeat 1275..1302 CDD:293787 11/26 (42%)
HEAT repeat 1502..1535 CDD:293787 13/34 (38%)
HEAT repeat 1545..1575 CDD:293787 12/29 (41%)
HEAT repeat 1584..1613 CDD:293787 13/28 (46%)
HEAT repeat 1624..1654 CDD:293787 9/29 (31%)
ecpasNP_001155958.1 Ecm29 10..514 CDD:289751 176/526 (33%)
HEAT repeat 429..461 CDD:293787 9/31 (29%)
HEAT repeat 471..498 CDD:293787 9/32 (28%)
HEAT repeat 507..532 CDD:293787 12/37 (32%)
HEAT repeat 1064..1095 CDD:293787 16/30 (53%)
HEAT repeat 1106..1132 CDD:293787 13/25 (52%)
Vac14_Fab1_bd 1125..1210 CDD:289521 42/106 (40%)
HEAT repeat 1144..1173 CDD:293787 13/28 (46%)
HEAT repeat 1188..1221 CDD:293787 17/32 (53%)
HEAT repeat 1236..1263 CDD:293787 11/26 (42%)
HEAT repeat 1350..1380 CDD:293787 10/29 (34%)
HEAT repeat 1390..1419 CDD:293787 11/28 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170578415
Domainoid 1 1.000 259 1.000 Domainoid score I1954
eggNOG 1 0.900 - - E1_KOG0915
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6056
Inparanoid 1 1.050 865 1.000 Inparanoid score I402
OMA 1 1.010 - - QHG55665
OrthoDB 1 1.010 - - D37669at33208
OrthoFinder 1 1.000 - - FOG0003485
OrthoInspector 1 1.000 - - oto40314
orthoMCL 1 0.900 - - OOG6_103321
Panther 1 1.100 - - LDO PTHR23346
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R364
SonicParanoid 1 1.000 - - X2852
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1716.800

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