Protein Alignment CG8858 and ECPAS

DIOPT Version :10

• Sequence 1: NP_610746.1
• Gene: CG8858 / 36319
• FlyBaseID: FBgn0033698
• Length: 1890
• Species: Drosophila melanogaster
• Sequence 2: NP_001351860.1
• Gene: ECPAS / 23392
• HGNCID: 29020
• Length: 1845
• Species: Homo sapiens
• Alignment Length: 1989
• Identity: 623/1989 - (31%)
• Similarity: 1007/1989 - (50%)
• Gaps: 266/1989 - (13%)

  Fly     8 EIELLERVLLRLGNADSDEKLEAAVGKFLTPVILKMNSPHNVVRTKVVEVLTHIKRRLSSRGHVQ 72
            |:..||||.||||:|::||:|:..:.|||.||:||::|....||.||:|:|.|:.:|:.||..:|
Human    12 ELNQLERVFLRLGHAETDEQLQNIISKFLPPVLLKLSSTQEGVRKKVMELLVHLNKRIKSRPKIQ 76

  Fly    73 IPVEALLDQYAAQDSSTFLKNFAIIFITMGFPRLALEQQTALA-SKVVGCEDKLESYQDKLFALL 136
            :|||.||.||....:.:|:.||.||::.||:|||.:|:|..|| :.:...|.|.:..||.|..||
Human    77 LPVETLLVQYQDPAAVSFVTNFTIIYVKMGYPRLPVEKQCELAPTLLTAMEGKPQPQQDSLMHLL 141

  Fly   137 LPVLSDMKIPDDPTQRSKLLDLQDKPAICANFLALLQDVLLLPYG--ITQEQ------------- 186
            :|.|..||.|.:.::.:...:|.:||......|..:.||||:|||  :.:.|
Human   142 IPTLFHMKYPVESSKSASPFNLAEKPKTVQLLLDFMLDVLLMPYGYVLNESQSRQNSSSAQGSSS 206

  Fly   187 ---------DVPPGLSPYSFTRIIAYN-WRAEELEKVKKGIVRFLCASVFSDLQIFVPLVVASAD 241
                     ..|||:|.|:..|:|..| |..|:||:.|.|||:|:.|....:|:..:.||:||:|
Human   207 NSGGGSGIPQPPPGMSFYAAKRVIGDNPWTPEQLEQCKLGIVKFIEAEQVPELEAVLHLVIASSD 271

  Fly   242 TRFSVATPAITELSKLCTMLDFSNPAVTAPLYTLFAGNQSKIT--------DRQTRPCCARVRQK 298
            ||.||||.|..||....:::|::|||:...:|.::.|:....|        :.:..|...||:.|
Human   272 TRHSVATAADLELKSKQSLIDWNNPAIINKMYKVYLGDIPLKTKEGAVLKPELKRDPVSTRVKLK 336

  Fly   299 LLQYLIKCRGKSINVTKGLQVTFDGFFGTNTNQKCKVLALQFMELLLRDGPRELVSKVSKVILTG 363
            ::.:|::.|..:......:||.:||.||||||.|.:.|:|||:..:....|...:..:..::|.|
Human   337 IVPHLLRSRQAAETFPANIQVVYDGLFGTNTNSKLRTLSLQFVHHICITCPEIKIKPLGPMLLNG 401

  Fly   364 ITKIIGRDSNEPNDVQNAAYSALAQHARSFPQDVSQDLKLVLGYFNNLASCAPELHSSIREALVS 428
            :||:|.....:|. :.:.||||:.:.:...|...::|:.||...|..|....||...:|:|||..
Human   402 LTKLINEYKEDPK-LLSMAYSAVGKLSSRMPHLFTKDIALVQQLFEALCKEEPETRLAIQEALSM 465

  Fly   429 MAPAFAWKTKEKSDAMEVDKNVDSSSVKLDGQQHLLLAMLLDNAESKVQI-VQNVTSVFLTSCYP 492
            |..|::                     .|:|.|..|:..|:.:...|.:: |:.|...|.::.:|
Human   466 MVGAYS---------------------TLEGAQRTLMEALVASYLIKPEVQVRQVAVKFASTVFP 509

  Fly   493 EYYAPARYLLLLIAGERNSLRENVTTYLYGTSKKDHINYSMLSSIDHSKNRISSESISDFNHLSL 557
            ..:.|:||||||.||:.   ||.|    :|.:::      :|..:. .:||  .||.|:
Human   510 SDHIPSRYLLLLAAGDP---REEV----HGEAQR------VLRCLP-GRNR--KESTSE------ 552

  Fly   558 EQRRVMLPSFQVMMSHVHEMAEKRLKKNTACVVVGRTKLPYSLEVYEELLDYLRLCLWYSAGVVA 622
                 .:|||..|:.::.|.|..|: |.....:.|.|.||::...:.|::.|||:||.:|||||.
Human   553 -----QMPSFPEMVYYIQEKASHRM-KTPVKYMTGTTVLPFNPAAFGEIVLYLRMCLAHSAGVVP 611

  Fly   623 -----------APGDEKYTHELREYITL----HYEDTEDNALHQYAQFVQRSVEAKRSESNLICL 672
                       ||...:|...|.....:    ..:..|.|.:..|...:|:.:........:.||
Human   612 TSQSLADMQDHAPAIGRYIRTLMSSGQMAPSSSNKSGETNPVQIYIGLLQQLLAGVGGLPVMYCL 676

  Fly   673 YDLLNAAPELFAAKQLHLLEPLGNTLKDVSETMRINVAQVYGILWAFGLSDEKFDEEVGECLNSL 737
            .:.::..||..|.|.:...|.:.:.:.:..|.||...|..|.::.:....:|         |.|:
Human   677 LEAVSVYPEKLATKFVDKTEWIKSLMNNSKEEMRELAALFYSVVVSTVSGNE---------LKSM 732

  Fly   738 TQKTL---------EHKHGWLLVVGHTFNR-----KIAMLKQENKTKDFAAWPQ----FVNAVKI 784
            .::.:         |.:||.||.:|.|..|     |:.|.:|::..::....|.    ..:|.:.
Human   733 IEQLIKTTKDNHSPEIQHGSLLALGFTVGRYLAKKKMRMSEQQDLERNADTLPDQEELIQSATET 797

  Fly   785 ISKCLCESQWLLVSAAVKCISMIGKAVEIPNVPVEIQVPSKDGDDDDEEMTEYTSIDSSTKLVIF 849
            |...|..:..||..||...:..||:...:|       :||:.              ...|||.:.
Human   798 IGSFLDSTSPLLAIAACTALGEIGRNGPLP-------IPSEG--------------SGFTKLHLV 841

  Fly   850 GVVFQLLRSSSARQKIREDSARCLGYLAIGDGEHFTKRNLDKFLTLTKIQKDAALNIAISEAIVN 914
            ..:...:.||....|::|.:.:.|||..:|||:...::.|.:.|..:...|...|...|.|||.:
Human   842 ESLLSRIPSSKETNKMKERAIQTLGYFPVGDGDFPHQKLLLQGLMDSVEAKQIELQFTIGEAITS 906

  Fly   915 TL----------------------CGYDVNKGQP--DEKFVNKHCNDDDFDQFLNSLIRLVTDPN 955
            ..                      .|..||...|  .:..:|||                :..||
Human   907 AAIGTSSVAARDAWQMTEEEYTPPAGAKVNDVVPWVLDVILNKH----------------IISPN 955

  Fly   956 PHSRQAISVWLLAVVKHCSQRPAVLAKKELLQFAFTELLSDDSEFVQDVASRGLGLVYSISDSGS 1020
            ||.|||..:|||::|:..|....|.:..:.:|.||..:||::.|..|||||:||||||.:.:...
Human   956 PHVRQAACIWLLSLVRKLSTHKEVKSHLKEIQSAFVSVLSENDELSQDVASKGLGLVYELGNEQD 1020

  Fly  1021 QSDLANSLLDQLIGGKRKVNQVTADTELFAEGMLGKTPTGGNITTYKELCSLASDLNQPDMIYQF 1085
            |.:|.::|::.|:.|||..::|:.:|.:|..|.|||||.|..::||||||||||||:|||::|:|
Human  1021 QQELVSTLVETLMTGKRVKHEVSGETVVFQGGALGKTPDGQGLSTYKELCSLASDLSQPDLVYKF 1085

  Fly  1086 MQLANHNATWTSKLGAAFGLKTLSAESRQKMEPYLGKIIPRLYRYKYDPTPKIQNSMISIWDTIV 1150
            |.||||:|.|.|:.|||||...::..:.:::.|:|.:::||||||::||...|:.:|.|||:.:|
Human  1086 MNLANHHAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSIWNALV 1150

  Fly  1151 TDSKEVTERYYWEILRELLDNLTCKEWRVRIACCLAVRDLL-NRPNGLKLRSEEPVRRALPDNSM 1214
            || |.:.::|..|||::|:.|||...||||.:.|||:.||| .||
Human  1151 TD-KSMVDKYLKEILQDLVKNLTSNMWRVRESSCLALNDLLRGRP-------------------- 1194

  Fly  1215 EVDEVPEPELKELWFQLFRVMDDIHEGTRVAAHGTASFLGKLCVIASSSDHGKSGTAVASSILPF 1279
             :|::.: :|.|:|..||||.|||.|..|.||......|.|:||.......|.:|....:::||.
Human  1195 -LDDIID-KLPEIWETLFRVQDDIKESVRKAAELALKTLSKVCVKMCDPAKGAAGQRTIAALLPC 1257

  Fly  1280 LLETGVGHKVPEIRRVSIKTISDMIDSSGSLIAPHLATLIPCLLRATGELENTKLSYVSTRLGAD 1344
            ||:.|:...|.|:|.:||.|:..:..|:|:::.||...|||.||.:...||...|:|:|.|  |.
Human  1258 LLDKGMMSTVTEVRALSINTLVKISKSAGAMLKPHAPKLIPALLESLSVLEPQVLNYLSLR--AT 1320

  Fly  1345 NEAQEAVDTLRAEAAKSLHTMETIGKCVRYIDYSVLEKMTPEVLELMKGSVNLGTKIGCAHFVCL 1409
            .:.:.|:|:.|..||||...||||..|::|:|.|||.::.|.:.||::..|.||||.|||..:..
Human  1321 EQEKAAMDSARLSAAKSSPMMETINMCLQYLDVSVLGELVPRLCELIRSGVGLGTKGGCASVIVS 1385

  Fly  1410 ISIRLGKEMTPLVGKYIRACFVGIKNRNATVRKYNASAIGHLLGLAKEQSIKSLFTKLEELYAEQ 1474
            ::.:..:::||..||.:.|...|:.:||:.::|..|.|:|||:..:::.|.:.|..||...|.|:
Human  1386 LTTQCPQDLTPYSGKLMSALLSGLTDRNSVIQKSCAFAMGHLVRTSRDSSTEKLLQKLNGWYMEK 1450

  Fly  1475 PG---NRSIALTIQSINKRHHELLKDYMDSMLPLIFFAMHEEPNEE--TKANVELWKDLWHDVSP 1534
            ..   ..|.||||.:|.:...::||::...:|||.|..|||..:||  .|....||.::|.:..|
Human  1451 EEPIYKTSCALTIHAIGRYSPDVLKNHAKEVLPLAFLGMHEIADEEKSEKEECNLWTEVWQENVP 1515

  Fly  1535 GD-AGIRLNLNVIIPKLESSLTDASWSRKAQAANAIQTIATRLSSSLDEPDRLRLIKLLLSGLQG 1598
            |. .||||.|..:|...:.:|...||..|||.|.|:.:|| :.:|||..|....::..||.||.|
Human  1516 GSFGGIRLYLQELITITQKALQSQSWKMKAQGAIAMASIA-KQTSSLVPPYLGMILTALLQGLAG 1579

  Fly  1599 RTFEGKERLLQALA----ALTKGLDR---NHQICSSIIDAAMREARKREPVYRTMALASLGEILD 1656
            ||:.|||.||:|:|    |.:..|::   |....:.|:.|.::|..|....|:.:|::...:||.
Human  1580 RTWAGKEELLKAIACVVTACSAELEKSVPNQPSTNEILQAVLKECSKENVKYKIVAISCAADILK 1644

  Fly  1657 QLEADRFEEVYNMSWNLLEKKELRKESDDEDEPNTSQELSADERNKRAQTLNRLKEVVWETLGKS 1721
            ..:.|||:|..|:...|::|..|     :.....|::....:|:.|..|....|.  .:|:|||:
Human  1645 ATKEDRFQEFSNIVIPLIKKNSL-----ESSGVRTTKNEEENEKEKELQLEYLLG--AFESLGKA 1702

  Fly  1722 WPRHSIETQHRYQLFFAENCTSILAESTRPVQVSLLAALTKYIERLHVFDESAQVPDLTQINQEK 1786
            |||:: |||..|:....:.....|..||..||:.:|.::..:.:.|.:.:|
Human  1703 WPRNA-ETQRCYRQELCKLMCERLKLSTWKVQLGVLQSMNAFFQGLMLLEE-------------- 1752

  Fly  1787 KIKTEETAPKTREAIVEKICTDVLAAVALAAGVPHSGLKKEALNIVLMLIKRLSGSGN----GNQ 1847
                |...|:....|:.:.|..:..::   ....:|.::.|||:::.:|:|:|..|..    .::
Human  1753 ----EHADPEALAEILLETCKSITYSL---ENKTYSSVRTEALSVIELLLKKLEESKQWECLTSE 1810

  Fly  1848 QPLRLIKQSFESNLEKFQRDSAPEIRCRIKDIEDKLSKL 1886
            ..:.||:     :|...:.||.||::.:...::..|..|
Human  1811 CRVLLIE-----SLATMEPDSRPELQEKAALLKKTLENL 1844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8858	NP_610746.1	Ecm29	20..504	CDD:463769	170/518 (33%)
		HEAT repeat	1164..1189	CDD:293787	13/24 (54%)
		HEAT repeat	1226..1259	CDD:293787	16/32 (50%)
		MMS19_C	<1274..1332	CDD:463594	22/57 (39%)
		HEAT repeat	1275..1302	CDD:293787	11/26 (42%)
		HEAT repeat	1502..1535	CDD:293787	13/34 (38%)
		HEAT repeat	1545..1575	CDD:293787	11/29 (38%)
		HEAT repeat	1584..1613	CDD:293787	14/32 (44%)
		HEAT repeat	1624..1654	CDD:293787	6/29 (21%)
ECPAS	NP_001351860.1	HEAT repeat	515..541	CDD:293787	13/38 (34%)
		HEAT 8. /evidence=ECO:0000255	683..720		10/36 (28%)
		HEAT 9. /evidence=ECO:0000255	721..759		9/46 (20%)
		HEAT 10. /evidence=ECO:0000255	783..820		8/36 (22%)
		HEAT 11. /evidence=ECO:0000255	829..868		11/52 (21%)
		HEAT 12. /evidence=ECO:0000255	870..907		11/36 (31%)
		HEAT 13. /evidence=ECO:0000255	931..969		17/53 (32%)
		HEAT 14. /evidence=ECO:0000255	975..1012		15/36 (42%)
		HEAT 15. /evidence=ECO:0000255	1013..1050		10/36 (28%)
		HEAT repeat	1084..1107	CDD:293787	14/22 (64%)
		HEAT 16. /evidence=ECO:0000255	1112..1149		15/36 (42%)
		HEAT repeat	1119..1152	CDD:293787	15/32 (47%)
		HEAT	1141..1226	CDD:480849	43/107 (40%)
		HEAT 17. /evidence=ECO:0000255	1152..1189		17/37 (46%)
		HEAT repeat	1162..1192	CDD:293787	17/29 (59%)
		HEAT 18. /evidence=ECO:0000255	1194..1231		16/58 (28%)
		HEAT repeat	1201..1230	CDD:293787	14/28 (50%)
		HEAT 19. /evidence=ECO:0000255	1243..1281		13/37 (35%)
		HEAT repeat	1251..1281	CDD:293787	11/29 (38%)
		HEAT 20. /evidence=ECO:0000255	1285..1323		15/39 (38%)
		HEAT 21. /evidence=ECO:0000255	1348..1386		16/37 (43%)
		HEAT 22. /evidence=ECO:0000255	1390..1427		12/36 (33%)
		HEAT repeat	1398..1427	CDD:293787	10/28 (36%)
		HEAT 23. /evidence=ECO:0000255	1517..1554		14/36 (39%)
		HEAT 24. /evidence=ECO:0000255	1558..1595		18/36 (50%)
		HEAT 25. /evidence=ECO:0000255	1605..1642		7/36 (19%)
		HEAT 26. /evidence=ECO:0000255	1646..1683		9/41 (22%)
		HEAT 27. /evidence=ECO:0000255	1779..1822		11/47 (23%)
		Ecm29	16..522	CDD:463769	178/527 (34%)
		HEAT 1. /evidence=ECO:0000305	28..65		17/36 (47%)
		HEAT 2. /evidence=ECO:0000305	107..144		14/36 (39%)
		HEAT 3. /evidence=ECO:0000305	162..205		12/42 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..217		1/23 (4%)
		HEAT 4. /evidence=ECO:0000305	326..362		9/35 (26%)
		HEAT 5. /evidence=ECO:0000255	387..426		11/39 (28%)
		HEAT repeat	396..428	CDD:293787	10/32 (31%)
		HEAT 6. /evidence=ECO:0000255	429..466		12/36 (33%)
		HEAT repeat	440..466	CDD:293787	10/25 (40%)
		HEAT 7. /evidence=ECO:0000255	469..507		10/58 (17%)
		HEAT repeat	475..506	CDD:293787	8/30 (27%)