DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8858 and Ecpas

DIOPT Version :9

Sequence 1:	NP_610746.1	Gene:	CG8858 / 36319	FlyBaseID:	FBgn0033698	Length:	1890	Species:	Drosophila melanogaster
Sequence 2:	NP_001342625.1	Gene:	Ecpas / 230249	MGIID:	2140220	Length:	1846	Species:	Mus musculus

Alignment Length:	2006	Identity:	616/2006 - (30%)
Similarity:	1003/2006 - (50%)	Gaps:	299/2006 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EIELLERVLLRLGNADSDEKLEAAVGKFLTPVILKMNSPHNVVRTKVVEVLTHIKRRLSSRGHVQ 72
            |:..||||.||||:|::||:|:..:.|||.||:||::|....||.||:|:|.|:.:|:.||..:|
Mouse    12 ELNQLERVFLRLGHAETDEQLQNIISKFLPPVLLKLSSTQEGVRKKVMELLVHLNKRIKSRPKIQ 76

  Fly    73 IPVEALLDQYAAQDSSTFLKNFAIIFITMGFPRLALEQQTALA-SKVVGCEDKLESYQDKLFALL 136
            :|||.||.||....:.:|:.||.||::.||:|||.:|:|..|| :.:...|.|.:..||.|..||
Mouse    77 LPVETLLVQYQDPAAVSFVTNFTIIYVKMGYPRLPVEKQCELAPTLLTAMEGKPQPQQDSLMHLL 141

  Fly   137 LPVLSDMKIPDDPTQRSKLLDLQDKPAICANFLALLQDVLLLPYG--ITQEQ------------- 186
            :|.|..||.|.:.::.:...:|.:||......|..:.||||:|||  :.:.|
Mouse   142 IPTLFHMKYPAESSKSASPFNLAEKPKTVQLLLDFMLDVLLMPYGYVLNESQSRQNSSSSSQGSS 206

  Fly   187 ----------DVPPGLSPYSFTRIIAYN-WRAEELEKVKKGIVRFLCASVFSDLQIFVPLVVASA 240
                      ..|||:|.|:..|:|..| |..|:||:.|.|||:|:.|....:|:..:.||:||:
Mouse   207 SNSGGGSGIPQPPPGMSFYAAKRVIGDNPWTPEQLEQCKLGIVKFIEAEQVPELEAVLHLVIASS 271

  Fly   241 DTRFSVATPAITELSKLCTMLDFSNPAVTAPLYTLFAGNQSKIT--------DRQTRPCCARVRQ 297
            |||.||||.|..||....:::|::|||:...:|.::.|:....|        :.:..|...||:.
Mouse   272 DTRHSVATAADLELKSKQSLIDWNNPAIINKMYKVYLGDIPLKTKEGAVLKPELKRDPVSTRVKL 336

  Fly   298 KLLQYLIKCRGKSINVTKGLQVTFDGFFGTNTNQKCKVLALQFMELLLRDGPRELVSKVSKVILT 362
            |::.:|::.|..:......:||.:||.||||||.|.:.|:|||:..:....|...:..:..::|.
Mouse   337 KIVPHLLRSRQAAETFPANIQVVYDGLFGTNTNSKLRTLSLQFVHHICLTCPEIKIKPLGPMLLN 401

  Fly   363 GITKIIGRDSNEPNDVQNAAYSALAQHARSFPQDVSQDLKLVLGYFNNLASCAPELHSSIREALV 427
            |:||:|.....:|. :.:.||||:.:.:...|...::|:.||...|..|....||...:|:|||.
Mouse   402 GLTKLINEYKEDPK-LLSMAYSAVGKLSSRMPHLFTKDIALVQQLFEALCKEEPETRLAIQEALS 465

  Fly   428 SMAPAFAWKTKEKSDAMEVDKNVDSSSVKLDGQQHLLLAMLLDNAESKVQI-VQNVTSVFLTSCY 491
            .|..|::                     .|:|.|..|:..|:.:...|.:: |:.|...|.::.:
Mouse   466 MMVGAYS---------------------TLEGAQRTLMEALVASYLIKPEVQVRQVAVKFASTVF 509

  Fly   492 PEYYAPARYLLLLIAG----ERNSLRENVTTYLYGTSKKDHINYSMLSSIDHSKNRISSESISDF 552
            |..:.|:||||||.||    |.:...:.|...|.|.:||:..:..|
Mouse   510 PSDHIPSRYLLLLAAGDPREEVHGEAQRVLRCLPGRNKKESASKQM------------------- 555

  Fly   553 NHLSLEQRRVMLPSFQVMMSHVHEMAEKRLKKNTACVVVGRTKLPYSLEVYEELLDYLRLCLWYS 617
                        |||..|:.::.|.|..|: |.....:.|.|.||::...:.|::.|||:||.:|
Mouse   556 ------------PSFPEMVYYIQEKASHRM-KTPVKYMTGTTVLPFNPAAFGEIVLYLRMCLAHS 607

  Fly   618 AGVVAAPGDEKYTHELREYITLHYEDTEDN--ALHQYAQFVQRSVEAKRSESN------------ 668
            ||||  |..:...            |.:|:  |:.:|.:.:..|.:|..|.||
Mouse   608 AGVV--PTSQSLA------------DMQDHAPAIGRYIRALMSSSQATASSSNKSGETNPVQIYT 658

  Fly   669 ---------------LICLYDLLNAAPELFAAKQLHLLEPLGNTLKDVSETMRINVAQVYGIL-- 716
                           :.||.:.::..||..|.|.:...|.:.:.:....|.||...|..|.::
Mouse   659 GLLQQLLAGVGGLPVMYCLLEAVSVYPEKLATKFVDKTEWIKSLMSSSKEEMRELAALFYSVVVS 723

  Fly   717 WAFGLSDEKFDEEVGECLNSLTQKTLEH-----KHGWLLVVGHTFNR-----KIAMLKQENKTKD 771
            ...|:       |:...:..|.:.|.::     :||.||.:|.|..|     ::.|.:|.:...|
Mouse   724 TVSGI-------ELKSMIEQLIKATKDNHSPEVQHGSLLALGFTVGRYLAKKRVRMAEQHDLETD 781

  Fly   772 FAAWPQ----FVNAVKIISKCLCESQWLLVSAAVKCISMIGKAVEIPNVPVEIQVPSKDGDDDDE 832
            ....|:    ..:|.:.|...|..:..||..||...:..||:...:|       :||:.
Mouse   782 ADLLPEQEEIIRSATETIGSFLDSTSPLLAIAACTALGEIGRNGPLP-------IPSEG------ 833

  Fly   833 EMTEYTSIDSSTKLVIFGVVFQLLRSSSARQKIREDSARCLGYLAIGDGEHFTKRNLDKFLTLTK 897
                    ...|||.:...:...:.||....|::|.:.:.|||..:|||....::.|.:.|..:.
Mouse   834 --------SGFTKLHLVESLLNRIPSSKETNKMKERAIQTLGYFPVGDGVFPHQKLLLQGLMDSV 890

  Fly   898 IQKDAALNIAISEAIVNTLCGYDVNKGQ-----PDEKFV---NKHCNDD---DFDQFLNSLIRLV 951
            ..|...|...|.|||.:...|.:....:     .:|:::   ....||.   ..|..||   :.:
Mouse   891 EAKQIELQFTIGEAITSAAIGTNSVAARDAWLVTEEEYIPPAGAKVNDVVPWVLDVILN---KHI 952

  Fly   952 TDPNPHSRQAISVWLLAVVKHCSQRPAVLAKKELLQFAFTELLSDDSEFVQDVASRGLGLVYSIS 1016
            ..||||.|||..:|||::|:..|....|.:..:.:|.||..:||::.|..|||||:||||||.:.
Mouse   953 ISPNPHVRQAACIWLLSLVRKLSTHREVKSHLKEIQSAFVSVLSENDELSQDVASKGLGLVYELG 1017

  Fly  1017 DSGSQSDLANSLLDQLIGGKRKVNQVTADTELFAEGMLGKTPTGGNITTYKELCSLASDLNQPDM 1081
            :...|.:|.::|::.|:.|||..::|:.:|.:|..|.|||||.|..::||||||||||||:|||:
Mouse  1018 NEQDQQELVSTLVETLMTGKRVKHEVSGETVVFQGGGLGKTPDGQGLSTYKELCSLASDLSQPDL 1082

  Fly  1082 IYQFMQLANHNATWTSKLGAAFGLKTLSAESRQKMEPYLGKIIPRLYRYKYDPTPKIQNSMISIW 1146
            :|:||.||||:|.|.|:.|||||...::..:.:::.|:|.:::||||||::||...|:.:|.|||
Mouse  1083 VYKFMNLANHHAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSIW 1147

  Fly  1147 DTIVTDSKEVTERYYWEILRELLDNLTCKEWRVRIACCLAVRDLL-NRPNGLKLRSEEPVRRALP 1210
            :.:||| |.:.::|..|||::|:.|||...||||.:.|||:.||| .||
Mouse  1148 NALVTD-KSMVDKYLKEILQDLIKNLTSNMWRVRESSCLALNDLLRGRP---------------- 1195

  Fly  1211 DNSMEVDEVPEPELKELWFQLFRVMDDIHEGTRVAAHGTASFLGKLCVIASSSDHGKSGTAVASS 1275
                 :|:|.: :|.|:|..||||.|||.|..|.||......|.|:||.......|.:|....:.
Mouse  1196 -----LDDVID-KLPEMWETLFRVQDDIKESVRKAAELALKTLSKVCVKMCDPAKGAAGQRTIAV 1254

  Fly  1276 ILPFLLETGVGHKVPEIRRVSIKTISDMIDSSGSLIAPHLATLIPCLLRATGELENTKLSYVSTR 1340
            :||.||:.|:...|.|:|.:||.|:..:..|:|:::.||...|||.||.:...||...|:|:|.|
Mouse  1255 LLPCLLDKGMMSPVTEVRALSINTLVKISKSAGAMLKPHAPKLIPALLESLSVLEPQVLNYLSLR 1319

  Fly  1341 LGADNEAQEAVDTLRAEAAKSLHTMETIGKCVRYIDYSVLEKMTPEVLELMKGSVNLGTKIGCAH 1405
              |..:.::.:|:.|..||||...||||..|::|:|.|||.::.|.:.||::..|.||||.|||.
Mouse  1320 --ATEQEKDVMDSARLSAAKSSPMMETINMCLQYLDVSVLGELVPRLCELIRSGVGLGTKGGCAS 1382

  Fly  1406 FVCLISIRLGKEMTPLVGKYIRACFVGIKNRNATVRKYNASAIGHLLGLAKEQSIKSLFTKLEEL 1470
            .:..::.:..:::||..||.:.|...|:.:||:.::|..|.|:|||:..:::.|.:.|..||...
Mouse  1383 VIVSLTTQCPQDLTPYSGKLMSALLSGLTDRNSVIQKSCAFAMGHLVRTSRDSSTEKLLQKLNGW 1447

  Fly  1471 YAEQPG---NRSIALTIQSINKRHHELLKDYMDSMLPLIFFAMHEEPNEE--TKANVELWKDLWH 1530
            |.|:..   ..|.||||.:|.:...::||::...:|||.|..|||..:||  .|....:|.::|.
Mouse  1448 YMEKDEPVYKTSCALTIHAIGRYSPDVLKNHAKEVLPLAFLGMHEIADEEKSEKEECNMWTEVWQ 1512

  Fly  1531 DVSPGD-AGIRLNLNVIIPKLESSLTDASWSRKAQAANAIQTIATRLSSSLDEPDRLRLIKLLLS 1594
            :..||. .||||.|..:|...:.:|...||..|||.|.|:.:| ::.:|||..|....::..|:.
Mouse  1513 ENVPGSFGGIRLYLQELITITQKALQSQSWKMKAQGAIAMASI-SKQTSSLVPPYLGMILSALMQ 1576

  Fly  1595 GLQGRTFEGKERLLQALA----ALTKGLDR---NHQICSSIIDAAMREARKREPVYRTMALASLG 1652
            ||.|||:.|||.||:|:|    |.:..|::   |....:.|:.|.::|..|....|:.:|::...
Mouse  1577 GLAGRTWAGKEELLKAIACVVTACSTELEKSVPNQPTTNEILQAVLKECCKENLKYKIVAISCAA 1641

  Fly  1653 EILDQLEADRFEEVYNMSWNLLEKKELRK------ESDDEDEPNTSQELSADERNKRAQTLNRLK 1711
            ::|...:.|||:|..::...|::|..|..      :::||:|         .||..:.::|..
Mouse  1642 DVLKATKEDRFQEFSDIVIPLIKKNSLESMGVRTTKAEDENE---------KERELQLESLLG-- 1695

  Fly  1712 EVVWETLGKSWPRHSIETQHRYQLFFAENCTSILAESTRPVQVSLLAALTKYIERLHVFDESAQV 1776
              .:|:|||:|||:. :||..|:....:.....|..||..||:.:|.::..:.:.|.:.:|
Mouse  1696 --AFESLGKAWPRNP-DTQRCYRQELCKLMCERLRLSTWKVQLGVLQSMNAFFQGLMLLEE---- 1753

  Fly  1777 PDLTQINQEKKIKTEETAPKTREAIVEKICTDVLAAVALAAGVPHSGLKKEALNIVLMLIKRLSG 1841
                          |...|:....|:.:.|..:..::   ....:|.::.|||::|.:|:|:|..
Mouse  1754 --------------EHADPEALAEILLETCKSITYSL---ENKTYSSVRTEALSVVELLLKKLEE 1801

  Fly  1842 SGNGNQQPLRLIKQSFES-----------NLEKFQRDSAPEIRCRIKDIEDKLSKL 1886
            :            :.:||           :|...:.|:.||::.:...::..|..|
Mouse  1802 A------------KQWESLTAECRGLLIESLATMETDNRPELQEKASVLKKTLESL 1845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8858	NP_610746.1	Ecm29	20..504	CDD:289751	170/519 (33%)
		HEAT repeat	1164..1189	CDD:293787	13/24 (54%)
		HEAT repeat	1226..1259	CDD:293787	16/32 (50%)
		HEAT repeat	1275..1302	CDD:293787	11/26 (42%)
		HEAT repeat	1502..1535	CDD:293787	12/34 (35%)
		HEAT repeat	1545..1575	CDD:293787	10/29 (34%)
		HEAT repeat	1584..1613	CDD:293787	13/32 (41%)
		HEAT repeat	1624..1654	CDD:293787	6/29 (21%)
Ecpas	NP_001342625.1	Ecm29	16..523	CDD:315639	178/528 (34%)
		HEAT repeat	397..429	CDD:293787	10/32 (31%)
		HEAT repeat	441..467	CDD:293787	10/25 (40%)
		HEAT repeat	476..507	CDD:293787	8/30 (27%)
		HEAT repeat	516..542	CDD:293787	10/25 (40%)
		HEAT repeat	1085..1108	CDD:293787	14/22 (64%)
		HEAT repeat	1120..1153	CDD:293787	15/32 (47%)
		HEAT repeat	1163..1193	CDD:293787	17/29 (59%)
		HEAT repeat	1202..1231	CDD:293787	14/28 (50%)
		HEAT repeat	1252..1282	CDD:293787	11/29 (38%)
		HEAT repeat	1399..1428	CDD:293787	10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835207
Domainoid	1	1.000	587	1.000	Domainoid score	I205
eggNOG	1	0.900	-	-		E1_KOG0915
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6056
Inparanoid	1	1.050	855	1.000	Inparanoid score	I427
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55665
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003485
OrthoInspector	1	1.000	-	-		oto93088
orthoMCL	1	0.900	-	-		OOG6_103321
Panther	1	1.100	-	-	LDO	PTHR23346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2852
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760