DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t3 and tbxas1

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_991172.2	Gene:	tbxas1 / 792041	ZFINID:	ZDB-GENE-030131-8805	Length:	546	Species:	Danio rerio

Alignment Length:	550	Identity:	153/550 - (27%)
Similarity:	239/550 - (43%)	Gaps:	89/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLIWLLLLTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPR 66
            |.:.|.||::..|.::....:......||.|  |   .|:..:|.|:..|..|   |:. .||..
Zfish    20 LTVCLFLLSLSLLYWYSISPFSNLERCGIKH--P---KPLPFIGNLMMFRNGF---FKS-QADLI 75

  Fly    67 NGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNRFESADAGDPMGALTLPLAKYHHWKES 131
            |...:|.|::|.:...:::.||:::|||::|.||.|.||..:.....||.. :|.:.|...||..
Zfish    76 NKYGRICGYYIGRRSTVIIADPDMLRQVMVKEFNKFPNRMTARGITKPMSD-SLIMLKGEQWKRV 139

  Fly   132 RQCMSQLFTSGRMRDVMYSQMLDVASDLEQYL-NRKLGDRLERVLPLGRMCQLYTTDVTGNLFYS 195
            |..::..|::.:|::::  .:::.|:  |..| |.|.....|....:.:....:|.||..::.:.
Zfish   140 RSILTPTFSAAKMKEMV--PLINTAT--ETLLRNLKSHAESENSFNIHKCFGCFTMDVIASVAFG 200

  Fly   196 LNVGGLRRGRSELITKTKELFNTN-----------------------PRKVLDFMSVFF------ 231
            ..|..........:.:..:.|..:                       |.|..|.|:.||
Zfish   201 TQVDSQNNPDDPFVHQASKFFAFSFFRPIMIFFMAFPFLLRLLAGLLPNKSRDEMNSFFTQCIQK 265

  Fly   232 LPKWTGVLKPKVFTEDYARYM------------RH--LVDDHHEPTKGDLINQLQHFQLSRSSNH 282
            :.|....|.|:...:|:.:.|            .|  :|:|..|.......|...:....||...
Zfish   266 MIKQRDDLSPEQRRKDFLQLMLDVRTNKKFLSVEHFDVVNDADEEAYDGHENSPANESTKRSQQK 330

  Fly   283 YSQHPDFVASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMT 347
            .....|.:..|:.|.|:||:||||..:.||.|.||..|:.|::|:.|:.|.|....|:.|..:..
Zfish   331 RMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHETVDYANVQE 395

  Fly   348 LPYLKMVCLEALRLYPAAAFVNRECTSSA-------SEGFSLQPHVDFIVPPGMPAYISILGLHR 405
            |.||.||..|:|||||.|..|.|:.....       .:|.||:      :|.|.        ||.
Zfish   396 LKYLDMVICESLRLYPPAFRVARDVEEDTVLNGQFLPKGASLE------IPTGF--------LHY 446

  Fly   406 DERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETC 470
            |...|.||..|.||||.||.....||..|:||||||..|:|.||..|::|:.:|||.:::.|..|
Zfish   447 DPEHWTEPTKFIPERFTPEAKARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNVLAC 511

  Fly   471 ERT------VSEIRFNPKSFML----ESEN 490
            |.|      .|.....||:.::    |.||
Zfish   512 EDTEIPLELKSHTTLGPKNGVMVKITEREN 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	142/508 (28%)
tbxas1	NP_991172.2	p450	51..536	CDD:278495	142/510 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820