Protein Alignment Cyp6t3 and CYP4F12

DIOPT Version :9

• Sequence 1: NP_610745.1
• Gene: Cyp6t3 / 36318
• FlyBaseID: FBgn0033697
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 134/552 - (24%)
• Similarity: 228/552 - (41%)
• Gaps: 116/552 - (21%)

  Fly     5 WLLLLTIVTLNFWLRHK-----YDYF----RSRGIPHLPPSSWSPMGNLGQLL----FLRISFGD 56
            |||||.:|  ..||..:     |.::    |.:..|..|..:|. .|:||.:.    .|:.|
Human    19 WLLLLLVV--GSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF-WGHLGLITPTEEGLKNS--- 77

  Fly    57 LFRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQV-----LIKNFNNFLNRFESADAGDPMG 116
              .|:.|....|....:|..|   |.:::..|:.||.:     .|...:|...||.....|:  |
Human    78 --TQMSATYSQGFTVWLGPII---PFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGE--G 135

  Fly   117 ALTLPLAKYHHWKESRQCMSQLFTSGRMRD--VMYSQMLDVASDLEQYLNRKLGDRLERVLPLGR 179
            .|   |:....|...|:.::..|....::.  .::::..::..|..|:|..:...||:    :..
Human   136 IL---LSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLD----MFE 193

  Fly   180 MCQLYTTDVTGNLFYSLNVGGLRRGRSELITKTKE---LFNTNPRKVLDFMSVFFLPKWTGVLKP 241
            ...|.|.|......:|.: ...:...||.|....|   |.....:.:|..|...:
Human   194 HISLMTLDSLQKCIFSFD-SHCQERPSEYIATILELSALVEKRSQHILQHMDFLY---------- 247

  Fly   242 KVFTEDYARYMR--HLVDDHHE----------PTKG--------------DLINQLQHFQLSRSS 280
             ..:.|..|:.|  .||.|..:          ||:|              |.|:.|   .||:..
Human   248 -YLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVL---LLSKDE 308

  Fly   281 NHYSQHPDFVASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAF--ISTATLSYD 343
            :..:...:.:.::|...:..|.:|:::.:.:.||.||:.|:.|||.|.|::|..  .....:.:|
Human   309 DGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWD 373

  Fly   344 TLMTLPYLKMVCLEALRLYPAAAFVNRECTSS--ASEGFSLQPHVDFIVPPGMPAYISILGLHRD 406
            .|..||:|.|...|:|||:|.|.|::|.||..  ..:|        .::|.|:...|.|:|:|.:
Human   374 DLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDG--------RVIPKGITCLIDIIGVHHN 430

  Fly   407 ERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCE 471
            ...||:|.|:||.||.||.|:...|:.:|||.|||..|||....:.::|:.:..:|..:
Human   431 PTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHF------ 489

  Fly   472 RTVSEIRFNPK--------SFMLESENEIYLR 495
                  ||.|.        ..::.:|..::||
Human   490 ------RFLPDHTEPRRKLELIMRAEGGLWLR 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	120/503 (24%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	121/506 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920