DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006524820.1	Gene:	Cyp4f40 / 631304	MGIID:	3645508	Length:	551	Species:	Mus musculus

Alignment Length:	564	Identity:	131/564 - (23%)
Similarity:	217/564 - (38%)	Gaps:	140/564 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLLLTIVTLNF---WLRHKYDYF----RSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLY 62
            |||...:....|   :|...|..:    |..|.|..|..:|. .|:||               :.
Mouse    46 WLLFFLVGISWFLARFLTQLYTLYAKCQRLCGFPQPPKKNWF-WGHLG---------------MS 94

  Fly    63 ADPRNGQAKIV--------GFFIFQ---TPALMVRDPELIRQVLIKN---------FNNFLNRFE 107
            .....|..::.        ||..:.   .|.:.:..|::||.||..:         |.:||..:.
Mouse    95 PPTEEGMKQVTELVTTYPQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDDIFYSFLKPWL 159

  Fly   108 S----ADAGDPMGALTLPLAKYHHWKESRQCMSQLFTSGRMR----------DVMYSQMLDVASD 158
            .    ..|||             .|...|:.::..|....::          ::|:::.|.:||.
Mouse   160 GDGLLVSAGD-------------KWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASG 211

  Fly   159 ----LEQYLNRKLG--DRLER-VLPLGRMCQ------------LYTTDVTGN--------LFYSL 196
                |..:.|..|.  |.|:: |......||            |.|..|..|        |.|.|
Mouse   212 GSTRLNMFENISLMTLDTLQKCVFSFNSNCQEKPSQYIAAILELSTLAVKRNEQLLMHVDLLYRL 276

  Fly   197 NVGGLRRGRSELITKTKELFNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMRHLVDD-HH 260
            ...|:|             |....|.|.||...             |..|.....::|..|| ..
Mouse   277 TPDGMR-------------FYKACRLVHDFTDA-------------VIQERRRTLLKHGGDDIIK 315

  Fly   261 EPTKGDLINQLQHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALMGFTLYELAKAPDIQER 325
            ...|...::.:....|::..:......:.:.::|...:..|.:|:::.:.:.||.||:.|:.|||
Mouse   316 AKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFRGHDTTASGLSWILYNLARHPEHQER 380

  Fly   326 LRSELREAF--ISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSAS--EGFSLQPHV 386
            .|.|::|..  .....:.:|.|..||:|.|...|:|||:|....|:|.||...|  :|
Mouse   381 CRQEVQELLRDRDPKEIEWDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDG------- 438

  Fly   387 DFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGV 451
             .|:|.|:...|:|.|.|.:...|.:|.|:||.||.||..:...|:::|||.|||..|||....:
Mouse   439 -RIIPKGVICIINIFGTHHNPTVWRDPEVYDPFRFDPENIQARSPLSFIPFSAGPRNCIGQTFAM 502

  Fly   452 LQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495
            .::|:.:...|.::.:...::   |.|..|: .:|.:|..::||
Mouse   503 SEMKVALALTLLRFRILPDDK---EPRRKPE-LILRAEGGLWLR 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	118/517 (23%)
Cyp4f40	XP_006524820.1	p450	79..542	CDD:365848	121/529 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010