Protein Alignment Cyp6t3 and cyp3a4.2

DIOPT Version :10

• Sequence 1: NP_610745.1
• Gene: Cyp6t3 / 36318
• FlyBaseID: FBgn0033697
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001015786.1
• Gene: cyp3a4.2 / 548503
• XenbaseID: XB-GENE-971750
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 533
• Identity: 156/533 - (29%)
• Similarity: 246/533 - (46%)
• Gaps: 89/533 - (16%)

  Fly     5 WLLLLTIVTL----NFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLR---ISFG-DLFRQL 61
            |:||..::.|    ..|   .|.||:..|||     ..:|:..:|..|..|   :.|. :.|::
 Frog    12 WILLAALLVLILLYGIW---PYGYFKKMGIP-----GPTPLPFIGTFLEFRKGMVQFDTECFKK- 67

  Fly    62 YADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNR--------FESADAGDPMGA 117
                   ..|:.|.:..:.|.|.:.||.:|:.:|:|. :.||.||        ||||
 Frog    68 -------YGKMWGTYDGRQPVLAIMDPAIIKTILVKECYTNFTNRRNFGLNGPFESA-------- 117

  Fly   118 LTLPLAKYHHWKESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGR--M 180
              :.:|:...||..|..:|..||||:::     :|..:..|....|.:.:...:|:..|...  :
 Frog   118 --ITIAEDEQWKRIRNVLSPTFTSGKLK-----EMFQIMKDYSDILVKNIQGYVEKDEPCATKDV 175

  Fly   181 CQLYTTDVTGNLFYSLNVGGLRRGRSELITKTKELFNT---NPRKVLDFMSVFFLPKWTGV---L 239
            ...|:.||..:..:|:|:..|.:.....:...|:|..|   :|..:|..:..|..|...|:   .
 Frog   176 IGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLKTGLLSPLLILVVIFPFLRPILEGLNLNF 240

  Fly   240 KPKVFTEDYARYMRHLVDDHHEPTKGDLINQLQHFQL---SR-------SSNHYSQHPDFVASQA 294
            .||.|||   .:|..:.....:..|||...::...||   ||       |:.|.:.....:.:|:
 Frog   241 VPKDFTE---FFMNAVTSFREKRKKGDHSGRVDLLQLMMDSRTTGGNDLSNKHKALTDAEIMAQS 302

  Fly   295 GIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEAL 359
            .|.::||:||:|..:.:..|.||..||:|:||..|:.......|:.:||.||.:.||.||..|.|
 Frog   303 VIFIVAGYETTSTALSYLFYNLATHPDVQQRLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETL 367

  Fly   360 RLYPAAAFVNRECTSSAS-EGFSLQPHVDFIVPPG----MPAYISILGLHRDERFWPEPCVFDPE 419
            ||:|.|..:.|....:.. .|.|        :|.|    :|||:    |.||..:||||..|.||
 Frog   368 RLFPPAGRLERVSKQNVEINGVS--------IPKGIVTLIPAYV----LQRDPEYWPEPEEFRPE 420

  Fly   420 RFGPE-RSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKS 483
            ||..| |:.|. |.|::|||.||..|||.|..:|.:|:.||.:|:.:.|..|..|:..:.|:...
 Frog   421 RFSKENRATHT-PFTFLPFGDGPRNCIGLRFALLSMKVAIVTLLQNFSVRPCAETLIPMEFSTIG 484

  Fly   484 FMLESENEIYLRF 496
            | |:.:..|.|:|
 Frog   485 F-LQPKKPIVLKF 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	CYP6-like	68..493	CDD:410679	136/457 (30%)
cyp3a4.2	NP_001015786.1	CYP3A	67..495	CDD:410743	137/467 (29%)