DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp2c67

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001019890.1	Gene:	Cyp2c67 / 545288	MGIID:	3612288	Length:	491	Species:	Mus musculus

Alignment Length:	513	Identity:	101/513 - (19%)
Similarity:	195/513 - (38%)	Gaps:	110/513 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLIWLLLLTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPM---GN--------LGQLL--FLRIS 53
            :::.|.|..::.|:.|.:..     :||  :|||.. :|:   ||        :||.|  |.: :
Mouse     5 VVLVLCLSFLLVLSLWRQRS-----ARG--NLPPGP-TPLPIIGNYHLIDMKDIGQCLTNFSK-T 60

  Fly    54 FGDLFRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNR-----FESADAGD 113
            :|.:|.               .:....|.:::...|.:::..|.:...|..|     |:....|.
Mouse    61 YGPVFT---------------LYFGSQPIVVLHGYEAMKEAFIDHGEEFSGRGRFPFFDKVTKGK 110

  Fly   114 PMGALTLPLAKYHH---WKESRQCMSQLFTSGRMRDV------MYSQMLDVASDLEQYLNRKLGD 169
            .:|        :.|   ||.:|     :||...:|::      :.:::.:.|..|.:.|.:..|.
Mouse   111 GIG--------FSHGNVWKATR-----VFTINTLRNLGMGKRTIENKVQEEAQWLMKELKKTNGL 162

  Fly   170 RLERVLPLG-RMCQLYTTDVTGNL-------FYSLNVGGLRRGRSELITKTKELFNTNPRKVLDF 226
            ..:....:| ..|.:..:.|..|.       |.|| :|.:......|.:...::||..| .::|:
Mouse   163 PCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSL-IGKVNECTEILSSPGCQIFNAVP-ILIDY 225

  Fly   227 M----SVFFLPKWTGVLKPKVFTEDYARYMRHLVDDHHEPTKGDLINQ---LQHFQLSRSSNHYS 284
            .    :.||        |...:.:.   |:...:.:|.|..  |:.|.   :.:|.:.|......
Mouse   226 CPGRHNKFF--------KNHTWIKS---YLLEKIKEHEESL--DVTNPRDFIDYFLIQRCQEKGI 277

  Fly   285 QHPDF----VASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDTL 345
            :|.::    :|:....::..|.|:.|:.|.|.|..|.|...|..:::.|:........:......
Mouse   278 EHMEYTIEHLATLVTDLVFGGTESLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDR 342

  Fly   346 MTLPYLKMVCLEALR---LYPAAAFVNRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDE 407
            ..:||...:..|..|   |.|.:......|.:...         ::.:|.|.....|:..:..|.
Mouse   343 NHMPYTNAMVHEVQRYVDLGPISLVHEVTCDTKFR---------NYFIPKGTQVMTSLTSVLHDS 398

  Fly   408 RFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQY 465
            ..:|.|.||||..|..:.........::||.||...|:|..|..::|.|.:..||:.:
Mouse   399 TEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLTTILQNF 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	94/481 (20%)
Cyp2c67	NP_001019890.1	p450	30..487	CDD:278495	94/481 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010