DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	136/571 - (23%)
Similarity:	224/571 - (39%)	Gaps:	132/571 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIWL----------LLLTIVTLNFW----LRHKYDYF----RSRGIPHLPPSSWSPMGNLGQLLF 49
            |.||          |||::|.::::    |...|..:    |..|.|..|..||. .|:||....
  Rat     6 LSWLGLGPMSASPWLLLSLVGVSWFLTRCLTQIYTLYAKCQRLCGFPQPPKRSWF-WGHLGMSPP 69

  Fly    50 LRISFGDLFRQLYADPRNGQAKIVGFFIFQ---TPALMVRDPELIRQVLIKN---------FNNF 102
            .......:...:...|:       ||..:.   .|.:.:..|::||.||..:         |.:|
  Rat    70 TEEGMKQMTELVATYPQ-------GFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDGIFYSF 127

  Fly   103 LNRFESADAGDPMGALTLPLAKYHHWKESRQCMSQLFTSGRMR----------DVMYSQMLDVAS 157
            |..:    .||  |.|.....|   |...|..::..|....::          ::|:::.|.:||
  Rat   128 LKPW----LGD--GLLVSASDK---WSRHRSMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLAS 183

  Fly   158 DLEQYLNRKLGDRLERVLPLGRMCQLYTTDVTGNLFYSLNVGGLRRGRSELITKTKEL----FNT 218
            ....:|     |..|.:       .|.|.|......:|.| ...:...||.|....||    ...
  Rat   184 GGSAHL-----DMFENI-------SLMTLDTLQKCVFSFN-SNCQEKPSEYIAAILELSALVVKR 235

  Fly   219 NPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMR--HLVDDH---------------------H 260
            |.:.:|....::.|            |.|..|:.:  |||.|.                     .
  Rat   236 NEQLLLHMDLLYRL------------TPDGRRFYKACHLVHDFTYAVIQERRRTLPKHGGDDVIK 288

  Fly   261 EPTKGDLINQLQHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALMGFTLYELAKAPDIQER 325
            ...|...::.:....||:..:......:.:.::|...:..|.:|:::.:.:.||.|||.|:.|||
  Rat   289 AKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQER 353

  Fly   326 LRSELREAF---------ISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSAS--EG 379
            .|.|::|..         .|...|..|.|..||:|.|...|:|||:|....|:|.||...|  :|
  Rat   354 CRQEVQELLRDRDSEEIECSCGVLLRDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDG 418

  Fly   380 FSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGC 444
                    .::|.|:...|:|...|.:...|.:|.|:||.||.||..:...|:.:|||.|||..|
  Rat   419 --------RVIPKGIICIINIFATHHNPTVWQDPEVYDPFRFDPENIQARSPLAFIPFSAGPRNC 475

  Fly   445 IGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495
            ||....:.::|:.:...|.::.|...::   |.|..|: .:|.:|:.::||
  Rat   476 IGQTFAMNEMKVAVALTLLRFRVLPDDK---EPRRKPE-LILRAEDGLWLR 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	120/511 (23%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	116/500 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010