DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t3 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001178915.1	Gene:	Cyp4f17 / 500801	RGDID:	1561655	Length:	524	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	136/536 - (25%)
Similarity:	224/536 - (41%)	Gaps:	84/536 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLLLTIVT------LNFWLRHKYD-YFRSRGIPHLPPSSWSPMGNL--------GQLLFLRIS- 53
            |.|||.:.|      :..|:...|| |.|.|..|..|...|. .|:|        |..|...:|
  Rat    19 WQLLLVVGTSLLLARILAWISAFYDNYCRLRCFPQPPSRHWF-WGHLNLVKNNEEGLQLLAEMSH 82

  Fly    54 -FGDL----FRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNRFESADAGD 113
             |.|:    ....|...|....|.:| .|.|.|| .|...|:|       |..||..:    .||
  Rat    83 QFQDIHLCWIGIFYPILRLIHPKFIG-PILQAPA-AVAPKEMI-------FYGFLKPW----LGD 134

  Fly   114 PMGALTLPLAKYHHWKESRQCMSQLFTSGRMRDVM--YSQMLDVASDLEQYLNRKLGDRLERVLP 176
              |.|   ::....|...|:.::..|....::..:  :::.:::.....|.|..|...||:
  Rat   135 --GLL---VSAGEKWSRQRRLLTPAFHFDILKPYVKNFNKSVNIMHAKWQRLTAKGSARLD---- 190

  Fly   177 LGRMCQLYTTDVTGNLFYSLNVGGLRRGRSELITKTKELFNT------NPRKVLDFMSVFFLPKW 235
            :.....|.|.|......:|.: ...:...||.|...:||.:.      .|...:||:  ::|..
  Rat   191 MFEHISLMTLDSLQKCVFSFD-SNCQESPSEYIAAIQELSSLIVKRHHQPFLYMDFL--YYLTA- 251

  Fly   236 TGVLKPKV------FTEDYARYMRHL-----VDDH-HEPTKGDLINQLQHFQLSRSSNHYSQHPD 288
            .|....|.      ||:...|..|..     ||:. ...||...::.:....|::..:......:
  Rat   252 DGRRFRKACDLVHNFTDAVIRERRRTLSSQSVDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDE 316

  Fly   289 FVASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAF--ISTATLSYDTLMTLPYL 351
            .:.::|...:..|.:|:::.:.:.||.||:.|:.|||.|.|:||..  .....:.:|.|..||:|
  Rat   317 DIRAEADTFMFGGHDTTASALSWILYNLARHPEHQERCRQEVRELLRDREPEEIEWDDLTQLPFL 381

  Fly   352 KMVCLEALRLYPAAAFVNRECTSSA--SEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPC 414
            .|...|:|||:|....::|.||...  .:|        .::|.|....|||.|:|.:...||:|.
  Rat   382 TMCIKESLRLHPPVTVISRCCTQDVVLPDG--------RVIPKGNDCIISIFGVHHNPSVWPDPE 438

  Fly   415 VFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRF 479
            |:||.||..|..:...|:.:|||.|||..|||....:.::|:.:...|.::.:...::   |.|.
  Rat   439 VYDPFRFDSENPQKRSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFRLLPDDK---EPRR 500

  Fly   480 NPKSFMLESENEIYLR 495
            .|: .:|.:|..::||
  Rat   501 KPE-LILRAEGGLWLR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	120/489 (25%)
Cyp4f17	NP_001178915.1	p450	52..514	CDD:278495	123/500 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010