DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	572	Identity:	127/572 - (22%)
Similarity:	211/572 - (36%)	Gaps:	171/572 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIWLLLLTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGN------LGQLLFLRISFGDLF-RQ 60
            |:.||||.:.:..::|..::.....:..|..||..|. .||      |.|:|.....|...: |.
Mouse    24 LLGLLLLLLKSAQYYLHRQWLIKSLQQFPPAPPPQWL-FGNTLKDQDLQQILLCVEKFPSTYVRW 87

  Fly    61 LYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVL-------IKNFNNFLNRFESADAGDPMGAL 118
            |:.:    .|::|           :.||:.::.:|       :::::.|.          |....
Mouse    88 LWGN----HARVV-----------IYDPDYMKVILGRSDPKVVRSYSFFA----------PWIGY 127

  Fly   119 TLPLAKYHHWKESRQCMSQLF-------TSGRMRD---VM---YSQMLDVASDLEQYLNRKLGDR 170
            .|.|.....|.:.|:.::..|       ..|.|.|   ||   :.|::|....||.|.:..| ..
Mouse   128 GLLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVMLDKWEQLVDQDCPLEIYQDISL-MT 191

  Fly   171 LERVLPLG------------RMCQLY---TTDVT-------------GNLFYSLNVGG------- 200
            :|.::...            |..:.|   ..|:|             .|..|||:..|
Mouse   192 METMMKCAFSYQGSVQLEDCRNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRSFYHAC 256

  Fly   201 ---------LRRGRSELITKTKELFNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMRHLV 256
                     :.|.|...:....||.....:|.|||:.:....:          |||    .:.|.
Mouse   257 QIAHKHTERVIRMRKAQLQNEAELEKFRKKKRLDFLDILLFAQ----------TED----GKSLS 307

  Fly   257 DDHHEPTKGDLINQLQHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALMGFTLYELAKAPD 321
            |:.                              |.::....:..|..|:::.:.:..|.||..|:
Mouse   308 DED------------------------------VRAEMDTFMFEGHNTTASGISWIFYALATHPE 342

  Fly   322 IQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSAS--EGFSLQP 384
            .|:|.|.|::....:..:::.:.|..:||..|...|||||||.....:||.:|..:  :|.||
Mouse   343 HQQRCREEVKSILGNGTSVTLNHLDQMPYTTMCIKEALRLYPPIPGASRELSSPVTFPDGCSL-- 405

  Fly   385 HVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRL 449
                  |.|....:|..|||.:.|..|...||||.||.|...|..|  .::||.||...|||.:.
Mouse   406 ------PKGFLVTLSFYGLHHNPRLRPNAEVFDPSRFAPGAPRQTH--AFLPFSAGTRNCIGKQF 462

  Fly   450 GVLQLKLGIVHILKQYWVETCERTVSEIRFNP-------KSFMLESENEIYL 494
            .:.:||:.:...|.::          |:..:|       ...:|:|:|.|||
Mouse   463 TMNELKVAVALTLLRF----------ELLPDPTRVPILVSKIVLKSKNGIYL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	114/531 (21%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	116/535 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010