DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and CYP4F3

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens

Alignment Length:	580	Identity:	138/580 - (23%)
Similarity:	234/580 - (40%)	Gaps:	172/580 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLLLTIVTLNFWLRHK-----YDYF----RSRGIPHLPPSSWSPMGNLG-------QLLF---L 50
            |||||.:..  .||..:     |.::    |.|..|..|..:|. :|:||       .||:   |
Human    19 WLLLLLVGA--SWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF-LGHLGLIHSSEEGLLYTQSL 80

  Fly    51 RISFGD--------------LFRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNN 101
            ..:|||              :|...|..|          .:|...|::.:|         |.|.:
Human    81 ACTFGDMCCWWVGPWHAIVRIFHPTYIKP----------VLFAPAAIVPKD---------KVFYS 126

  Fly   102 FLNRFESADAGDPMGALTLPLAKYHHWKESRQCMSQLFTSGRMR----------DVMYSQMLDVA 156
            ||..:    .||  |.|   |:....|...|:.::..|....::          ::|:::...:|
Human   127 FLKPW----LGD--GLL---LSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA 182

  Fly   157 S------DLEQYLNRKLGDRLER-VLPLGRMCQLYTTDVTGNLFYSLNVGGLRRGRSELITKTKE 214
            |      |:.::::....|.|:: |......||...::....:.          ..|.|:||..:
Human   183 SEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAIL----------ELSALVTKRHQ 237

  Fly   215 ---LFNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMR--HLVDDHHE----------PTK 264
               |:       :||:  ::|            |.|..|:.|  .||.|..:          |::
Human   238 QILLY-------IDFL--YYL------------TPDGQRFRRACRLVHDFTDAVIQERRRTLPSQ 281

  Fly   265 G--------------DLINQLQHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALMGFTLYE 315
            |              |.|:.|   .||:..:......:.:.::|...:..|.:|:::.:.:.||.
Human   282 GVDDFLQAKAKSKTLDFIDVL---LLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYH 343

  Fly   316 LAKAPDIQERLRSELREAF--ISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSS--A 376
            |||.|:.|||.|.|::|..  .....:.:|.|..||:|.|...|:|||:|....|:|.||..  .
Human   344 LAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVL 408

  Fly   377 SEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGP 441
            .:|        .::|.|:...||:.|.|.:...||:|.|:||.||.|:..:...|:.:|||.|||
Human   409 PDG--------RVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGP 465

  Fly   442 HGCIGSRLGVLQLK--LGIV----HILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495
            ..|||....:.::|  ||:.    .:|..:         :|.|..|: .:|.:|..::||
Human   466 RNCIGQAFAMAEMKVVLGLTLLRFRVLPDH---------TEPRRKPE-LVLRAEGGLWLR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	123/531 (23%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	126/543 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920