DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp6u1

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	133/514 - (25%)
Similarity:	229/514 - (44%)	Gaps:	62/514 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLIWLLLLTIV------TLNFWLRHKYDYFRSRGIPHLPPS-SWSPMGNLGQLLFLRISFGDLFR 59
            ||..|..|::|      :|.:|.|        |||.|..|. .|   ||:..::..:....|..:
  Fly     8 LLTALGALSVVYALVKFSLGYWKR--------RGILHEKPKFLW---GNIKGVVSGKRHAQDALQ 61

  Fly    60 QLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNR-FESADAGDPMGALTLPLA 123
            .:|. ...|:|..|||:....|.::..|.:|:.|::..:..:|.:| ..|..:|:|:....|.|
  Fly    62 DIYT-AYKGRAPFVGFYACLKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPLSHNLLQL- 124

  Fly   124 KYHHWKESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTTDV 188
            ..|.|:......:::||...|:     ::|...|.:...:.|.||::..:.:.:..:...|.|||
  Fly   125 DGHKWRSLHAKSAEVFTPANMQ-----KLLVRLSQISSRIQRDLGEKSLQTINISELVGAYNTDV 184

  Fly   189 TGNLFYSLNVGGLRRGRSELITKTKELFNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMR 253
            ..::.:.| ||   :...|....|:..: .:.|....::::.| |....:|:.|.:.|....|.:
  Fly   185 MASMAFGL-VG---QDNVEFAKWTRNYW-ADFRMWQAYLALEF-PLIARLLQYKSYAEPATAYFQ 243

  Fly   254 HLVDDHHEPTKGDLINQLQ-HFQLSRS---------SNHYSQHPDF-VASQAGIILLAGFETSSA 307
            .:.           ::||| |.:..|.         ||......|. :|.||...:|||....:|
  Fly   244 KVA-----------LSQLQLHRRRDRQPLQTFLQLYSNAEKPLTDIEIAGQAFGFVLAGLGPLNA 297

  Fly   308 LMGFTLYELAKAPDIQERLRSELREAFIS-TATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRE 371
            .:.|.|||||:.|::|:|.|.|:.:|... ...::.:.|..|.|.|.|..|.|||:....|:.|.
  Fly   298 TLAFCLYELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLRR 362

  Fly   372 CTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHP-MTYI 435
            .|..    |.: |...|::..|....|....:|.|...:..|..|.|||| .|::|...| ..::
  Fly   363 ATKE----FEV-PGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERF-EEQARRSRPAAAFL 421

  Fly   436 PFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYL 494
            |||.|..|||.:|....||.:|:|.:|:|:.......|...:.::.:..:|..:::|.|
  Fly   422 PFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	118/466 (25%)
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	119/469 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461086
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900