DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	521	Identity:	152/521 - (29%)
Similarity:	239/521 - (45%)	Gaps:	72/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLLTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPRNGQA 70
            ||.:.:|.|..:....:..|:.:|||     ...|:..||.:|...........:.|    ....
Mouse    14 LLAIILVLLYRYGTRTHGLFKKQGIP-----GPKPLPFLGTVLNYYTGIWKFDMECY----EKYG 69

  Fly    71 KIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGALT--LPLAKYHHWKESR 132
            |..|.|..|||.|::.|||.|:.||:|: .:.|.||.|..    |:|.::  :.::|...||..|
Mouse    70 KTWGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNRREFG----PVGIMSKAISISKDEEWKRYR 130

  Fly   133 QCMSQLFTSGRMRDVMYSQMLDVASDLEQY---LNRKLGDRLERVLPLGRMCQL--YTTDVTGNL 192
            ..:|..|||||::     :|..|   :|||   |.:.|....|:.:|:.....|  |:.||..:.
Mouse   131 ALLSPTFTSGRLK-----EMFPV---IEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMDVITST 187

  Fly   193 FYSLNVGGLRRGRSELITKTKELFNTNPRKVLDF-----MSVFFLPKWTGV---LKPKVFTEDYA 249
            .:.:||..|.......:.:.|:...      :||     .||...|..|.|   |...:|..|..
Mouse   188 SFGVNVDSLNNPEDPFVEEAKKFLR------VDFFDPLLFSVVLFPLLTPVYEMLNICMFPNDSI 246

  Fly   250 RYMRHLVD-------DHHEPTKGDLINQLQHFQLSRSSNHYSQHPDF--------VASQAGIILL 299
            .:.:..||       |.::..:.|.:      ||..:|::.|:..|.        :..|:.|.:.
Mouse   247 EFFKKFVDRMQESRLDSNQKHRVDFL------QLMMNSHNNSKDKDSHKAFSNMEITVQSIIFIS 305

  Fly   300 AGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPA 364
            ||:||:|:.:.||||.||..||||::|::|:.:|..:.||.:.||:|.:.||.||..|.|||||.
Mouse   306 AGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNKATPTCDTVMEMEYLDMVLNETLRLYPI 370

  Fly   365 AAFVNRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHI 429
            ...:.|.|.......       ...:|.|....|....||.|.:.||:|..|.||||..|....|
Mouse   371 VTRLERVCKKDVELN-------GVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSI 428

  Fly   430 HPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYL 494
            .|..|:|||.||..|||.|..::.:||.:..:|:.:..:.|:.|...::.: :..:|:.|..|.|
Mouse   429 DPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLS-RQGILQPEKPIVL 492

  Fly   495 R 495
            :
Mouse   493 K 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	140/482 (29%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	145/496 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820