DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t3 and Cyp4f4

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_775146.1	Gene:	Cyp4f4 / 286904	RGDID:	708363	Length:	522	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	137/578 - (23%)
Similarity:	224/578 - (38%)	Gaps:	164/578 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LIWLLLLTIVTLNFW-----LRHKYDYFRSR----GIPHLPPSSWSPMGNLGQLLFLRISFGDLF 58
            |.|||||.|..  .|     |...|.::|:.    ..|..|..:|. :|:||.:.........:.
  Rat    17 LPWLLLLLIGA--SWLLVRVLTQTYIFYRTYQHLCDFPQPPKWNWF-LGHLGMITPTEQGLKQVT 78

  Fly    59 RQLYADPRNGQAKIVGFFIFQTPALMV---RDPELIRQVLIKN---------FNNFLNRFESADA 111
            :.:...|:       ||..:..|.|.:   ..|::||.||..:         |.:||..:    .
  Rat    79 KLVATYPQ-------GFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSFLKPW----L 132

  Fly   112 GDPMGALTLPLAKYHHWKESRQCMSQLFTSGRMR----------DVMYSQMLDVASD----LEQY 162
            ||  |.|   |:....|...|:.::..|....::          ::|:::..|:||.    |:.:
  Rat   133 GD--GLL---LSDGDKWSCHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLASGGSARLDMF 192

  Fly   163 LNRKLG--DRLER-VLPLGRMCQ------------------------LYTTDVTGNLFYSLNVGG 200
            .|..|.  |.|:: |......||                        |..||    ..|.|...|
  Rat   193 KNISLMTLDSLQKCVFSFDSNCQEKPSEYISAILELSALVAKRYQQLLLHTD----SLYQLTHNG 253

  Fly   201 LR----------------RGRSELITKTKE--LFNTNPR-KVLDFMSVFFLPKWTGVLKPKVFTE 246
            .|                :||...:....|  :.....| |.|||:.|..|            |:
  Rat   254 RRFHKACKLVHNFTDAVIQGRRRALPSQHEDDILKAKARSKTLDFIDVLLL------------TK 306

  Fly   247 DYARYMRHLVDDHHEPTKGDLINQLQHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALMGF 311
            |         :|..|.:..|                       :.::|...:..|.:|:::.:.:
  Rat   307 D---------EDGKELSDED-----------------------IRAEADTFMFEGHDTTASGLSW 339

  Fly   312 TLYELAKAPDIQERLRSELREAF--ISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTS 374
            .||.||:.|:.|||.|.|:||..  ..:..:.:|.|..||:|.|...|:|||:|....::|.||.
  Rat   340 ILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQ 404

  Fly   375 S--ASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPF 437
            .  ..:|        .::|.|:...|:|...|.:...||:|.|:||.||.||..:...|:.:|||
  Rat   405 DIVLPDG--------RVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPF 461

  Fly   438 GAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495
            .|||..|||....:.::|:.:...|.::.|...::   |.|..|: .:|.:|..::||
  Rat   462 SAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDK---EPRRKPE-LILRAEGGLWLR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	121/527 (23%)
Cyp4f4	NP_775146.1	CYP4F	74..515	CDD:410772	118/516 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010