DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	133/546 - (24%)
Similarity:	219/546 - (40%)	Gaps:	104/546 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLLL------TIVTLNFWLRHKYD-YFRSRGIPHLPPSSW-----SPMGNLGQLLFLRISFGDL 57
            |.|||      .:..:..|:...|| ..|.|..|..|..||     :.|.|..:.:......|..
  Rat    20 WHLLLLGGASWILARILAWIYTFYDNCCRLRCFPQPPKPSWFWGHLTLMKNNEEGMQFIAHLGRN 84

  Fly    58 FRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVL-----IKNFNNFLNRFESADAGDPMGA 117
            ||.::       ...||...   |.|.:..|.:|..:|     :......|..|.....||  |.
  Rat    85 FRDIH-------LSWVGPVY---PILRLVHPNVIAPLLQASAAVAPKEMTLYGFLKPWLGD--GL 137

  Fly   118 LTLPLAKYHHWKESRQCMSQLFTSGRMRDV--MYSQMLDVASDLEQYLNRKLGDRLERVLPLGRM 180
            |   ::....|...|:.::..|....::..  ::::.::......|.|..|...||:    :...
  Rat   138 L---MSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKGSARLD----MFEH 195

  Fly   181 CQLYTTDVTGNLFYSLNVGGLRRGRSELITKTKELFN------TNPRKVLDFMSVFFLP------ 233
            ..|.|.|......:|.: ...:...||.|....||.:      ..|...|||:  ::|.
  Rat   196 ISLMTLDSLQKCIFSFD-SNCQESNSEYIAAILELSSLIVKRQRQPFLYLDFL--YYLTADGRRF 257

  Fly   234 -KWTGVLKPKVFTEDYARYMRHLVDDHHEPTKG--------------DLINQLQHFQLSRSSNHY 283
             |...|:..  ||:...|..|..::     |:|              |.|:.|    |.....|.
  Rat   258 RKACDVVHN--FTDAVIRERRSTLN-----TQGVDEFLKARAKTKTLDFIDVL----LLAKDEHG 311

  Fly   284 SQHPDF-VASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAF--ISTATLSYDTL 345
            ....|. :.::|...:..|.:|:::.:.:.||.||:.|:.|||.|.|:||..  .....:.:|.|
  Rat   312 KGLSDVDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDL 376

  Fly   346 MTLPYLKMVCLEALRLYPAAAFVNRECTSSASEGFSLQPHVDFIVPPG--MP----AYISILGLH 404
            ..||:|.|...|:|||:|....::|.|:.            |.::|.|  :|    ..|||.|:|
  Rat   377 AQLPFLTMCIKESLRLHPPVLLISRCCSQ------------DIVLPDGRVIPKGNICVISIFGVH 429

  Fly   405 RDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVET 469
            .:...||:|.|::|.||.||..:...|:.:|||.|||..|||....:.::|:.:...|.::.|..
  Rat   430 HNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFCVLP 494

  Fly   470 CERTVSEIRFNPKSFMLESENEIYLR 495
            .::   |.|..|: .:|.:|..::||
  Rat   495 DDK---EPRRKPE-LILRAEGGLWLR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	119/499 (24%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	122/510 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010