DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t3 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	157/525 - (29%)
Similarity:	245/525 - (46%)	Gaps:	77/525 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLLLTIVTLNFWL-RHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPRNG 68
            |:||..|:.|.:.| .|::..|:.:|||     ...|:..||.:|......|....:.|    ..
  Rat    12 WVLLAVILVLLYRLGTHRHGIFKKQGIP-----GPKPLPFLGTVLNYYKGLGRFDMECY----KK 67

  Fly    69 QAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGAL--TLPLAKYHHWKE 130
            ..||.|.|..|||...:.|.|:|:.||:|. |:.|.||   .|.| |:|.:  .:.:||...||.
  Rat    68 YGKIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNR---RDFG-PVGIMGKAVSVAKDEEWKR 128

  Fly   131 SRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVL----------PLGRMCQLYT 185
            .|..:|..|||||::     :|..:   :|||     ||.|.:.|          .:.::...|:
  Rat   129 YRALLSPTFTSGRLK-----EMFPI---IEQY-----GDILVKYLKQEAETGKPVTMKKVFGAYS 180

  Fly   186 TDVTGNLFYSLNVGGLRRGRSELITKTKELFNTNPRKVLDFMSVFFLPKWTGV---LKPKVFTED 247
            .||..:..:.:||..|...:...:.|||:|...:....| |:||...|..|.:   |...:|.:|
  Rat   181 MDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPL-FLSVVLFPFLTPIYEMLNICMFPKD 244

  Fly   248 YARYMRHLV--------DDHHEPTKGDLINQLQHFQLSRSSNHYSQ----HPDF----VASQAGI 296
            ...:.:..|        |..|:       :::...||..::::.|:    |...    :.:|:.|
  Rat   245 SIAFFQKFVHRIKETRLDSKHK-------HRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQSVI 302

  Fly   297 ILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRL 361
            .:.||:||:|:.:.|.||.||..||||::|:.|:..|..|.|..:||.:|.:.||.||..|.|||
  Rat   303 FIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSKAPPTYDIVMEMEYLDMVLNETLRL 367

  Fly   362 YPAAAFVNRECTSSAS-EGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPER 425
            ||....:.|.|..... :|        ..:|.|....|....||.|.:.||:|..|.||||..|.
  Rat   368 YPIGNRLERVCKKDIELDG--------LFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKEN 424

  Fly   426 SRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESEN 490
            ...|.|..|:|||.||..|||.|..::.:||.:..:|:.:..:.|:.|...::.: :..:||.|.
  Rat   425 KGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLS-RQAILEPEK 488

  Fly   491 EIYLR 495
            .|.|:
  Rat   489 PIVLK 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	141/484 (29%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	139/459 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920