DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t3 and CYP4X1

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_828847.1	Gene:	CYP4X1 / 260293	HGNCID:	20244	Length:	509	Species:	Homo sapiens

Alignment Length:	551	Identity:	136/551 - (24%)
Similarity:	224/551 - (40%)	Gaps:	121/551 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLLTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYAD-PRNGQ 69
            |.|..:..:..:||.:......|..| .||:.|.    ||...|::....:...::... ||...
Human    22 LALGLLQAIKLYLRRQRLLRDLRPFP-APPTHWF----LGHQKFIQDDNMEKLEEIIEKYPRAFP 81

  Fly    70 AKIVGFFIFQTPALMVRDPELIRQVLIKN--FNNFLNRFESADAGDPMGALTLPLAKYHHWKESR 132
            ..|..|..|    ..:.||:..:.:|.:.  .:.:|.:|.....|..:.||..|     .|.:.|
Human    82 FWIGPFQAF----FCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGP-----KWFQHR 137

  Fly   133 QCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTTDVTGNLFYSLN 197
                :|.|.|...:::.:.:..:|..::..|     |:.|::      |.  |.|.:..::..:|
Human   138 ----RLLTPGFHFNILKAYIEVMAHSVKMML-----DKWEKI------CS--TQDTSVEVYEHIN 185

  Fly   198 VGGLRRGRSELITK---TKEL-FNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMRHLVDD 258
            ...|     ::|.|   :||. ..||........::|.|.|   ::..::::..|
Human   186 SMSL-----DIIMKCAFSKETNCQTNSTHDPYAKAIFELSK---IIFHRLYSLLY---------- 232

  Fly   259 HHEPTKGDLINQLQ----HFQ-LSRSSNHYS-----------------------QHPDF------ 289
                 ..|:|.:|.    .|| |||..|.|:                       ::.||
Human   233 -----HSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLS 292

  Fly   290 -------------VASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLS 341
                         |.|:....||||.:|.:|.:.:.||.||..|:.|||.|.|:|......::::
Human   293 AKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSIT 357

  Fly   342 YDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSAS--EGFSLQPHVDFIVPPGMPAYISILGLH 404
            :|.|..:.|..|...|..||.||...::|:.:...:  :|.:|        |.|:...:||.|||
Human   358 WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTL--------PAGITVVLSIWGLH 414

  Fly   405 RDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVET 469
            .:...|..|.||||.||..|.|...||..|:||.||...|||....:::||:.|..||..:.| |
Human   415 HNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV-T 478

  Fly   470 CERTVSEIRFNPKSFMLESENEIYLRFCRSS 500
            .:.| ..:.| |..|:|:.:|.:||...:.|
Human   479 PDPT-RPLTF-PNHFILKPKNGMYLHLKKLS 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	125/507 (25%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	128/518 (25%)
CYP4X1	NP_828847.1	heme binding region	447..460		6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010