Protein Alignment Cyp6t3 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_610745.1
• Gene: Cyp6t3 / 36318
• FlyBaseID: FBgn0033697
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 136/551 - (24%)
• Similarity: 224/551 - (40%)
• Gaps: 121/551 - (21%)

  Fly     6 LLLLTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYAD-PRNGQ 69
            |.|..:..:..:||.:......|..| .||:.|.    ||...|::....:...::... ||...
Human    22 LALGLLQAIKLYLRRQRLLRDLRPFP-APPTHWF----LGHQKFIQDDNMEKLEEIIEKYPRAFP 81

  Fly    70 AKIVGFFIFQTPALMVRDPELIRQVLIKN--FNNFLNRFESADAGDPMGALTLPLAKYHHWKESR 132
            ..|..|..|    ..:.||:..:.:|.:.  .:.:|.:|.....|..:.||..|     .|.:.|
Human    82 FWIGPFQAF----FCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAALDGP-----KWFQHR 137

  Fly   133 QCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTTDVTGNLFYSLN 197
                :|.|.|...:::.:.:..:|..::..|     |:.|::      |.  |.|.:..::..:|
Human   138 ----RLLTPGFHFNILKAYIEVMAHSVKMML-----DKWEKI------CS--TQDTSVEVYEHIN 185

  Fly   198 VGGLRRGRSELITK---TKEL-FNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMRHLVDD 258
            ...|     ::|.|   :||. ..||........::|.|.|   ::..::::..|
Human   186 SMSL-----DIIMKCAFSKETNCQTNSTHDPYAKAIFELSK---IIFHRLYSLLY---------- 232

  Fly   259 HHEPTKGDLINQLQ----HFQ-LSRSSNHYS-----------------------QHPDF------ 289
                 ..|:|.:|.    .|| |||..|.|:                       ::.||
Human   233 -----HSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLS 292

  Fly   290 -------------VASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLS 341
                         |.|:....||||.:|.:|.:.:.||.||..|:.|||.|.|:|......::::
Human   293 AKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSIT 357

  Fly   342 YDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSAS--EGFSLQPHVDFIVPPGMPAYISILGLH 404
            :|.|..:.|..|...|..||.||...::|:.:...:  :|.:|        |.|:...:||.|||
Human   358 WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTL--------PAGITVVLSIWGLH 414

  Fly   405 RDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVET 469
            .:...|..|.||||.||..|.|...||..|:||.||...|||....:::||:.|..||..:.| |
Human   415 HNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV-T 478

  Fly   470 CERTVSEIRFNPKSFMLESENEIYLRFCRSS 500
            .:.| ..:.| |..|:|:.:|.:||...:.|
Human   479 PDPT-RPLTF-PNHFILKPKNGMYLHLKKLS 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	CYP6-like	68..493	CDD:410679	119/479 (25%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	122/495 (25%)
		heme binding region	447..460		6/12 (50%)