DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp3a23-3a1

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	143/511 - (27%)
Similarity:	240/511 - (46%)	Gaps:	51/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLLLTIVTL--NFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLY---AD 64
            |:||..::.|  .|..| .:..|:.:|||     ...|:...|.:|       :.:..|:   .:
  Rat    12 WVLLAVVLVLLYGFGTR-THGLFKKQGIP-----GPKPLPFFGTVL-------NYYMGLWKFDVE 63

  Fly    65 PRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGAL--TLPLAKYH 126
            ......||.|.|..|.|...:.|.|:|:.||:|. |:.|.||   .|.| |:|.:  .:.::|..
  Rat    64 CHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNR---RDFG-PVGIMGKAISVSKDE 124

  Fly   127 HWKESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTTDVTGN 191
            .||..|..:|..|||||::: |:..:......|.:||.::.|    :.:|:..:...|:.||..:
  Rat   125 EWKRYRALLSPTFTSGRLKE-MFPVIEQYGDILVKYLRQEKG----KPVPVKEVFGAYSMDVITS 184

  Fly   192 LFYSLNVGGLRRGRSELITKTKELFNTNPRKVLDFMSVFFLPKWTGVLK-------PKVFTEDYA 249
            ..:.:||..|...:...:.|.|:|...:....| |:||...|..|.|.:       ||...|.:.
  Rat   185 TSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPL-FLSVVLFPFLTPVYEMLNICMFPKDSIEFFK 248

  Fly   250 RYMRHLVDDHHEPTKGDLINQLQ-----HFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALM 309
            :::..:.:...:..:...::.||     |.......:|.:.....:.:|:.|.:.||:|.:|:.:
  Rat   249 KFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQSIIFIFAGYEPTSSTL 313

  Fly   310 GFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTS 374
            .|.|:.||..||.|::|:.|:..|..:.|..:|||:|.:.||.||..|.|||||....:.|.|..
  Rat   314 SFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKK 378

  Fly   375 SASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGA 439
            .........|....::   :|:|    .||||.:.||||..|.||||..|....|.|..|:|||.
  Rat   379 DVEINGVFMPKGSVVM---IPSY----ALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFGN 436

  Fly   440 GPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495
            ||..|||.|..::.:||.:..:|:.:..:.|:.|...::.: :..:|:....|.|:
  Rat   437 GPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLS-RQGLLQPTKPIILK 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	130/469 (28%)
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	134/483 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920