DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and erg5

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_593788.2	Gene:	erg5 / 2542469	PomBaseID:	SPAC19A8.04	Length:	543	Species:	Schizosaccharomyces pombe

Alignment Length:	478	Identity:	109/478 - (22%)
Similarity:	187/478 - (39%)	Gaps:	93/478 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YD---YFRSRGIPHLP-PSSWSP-MGNLGQLLFLRISFGDLFRQLYADPRNGQAKIVGFFIFQTP 81
            ||   |...:|  |:| |....| ||:     ||. |....|.:..|..:.|....|.  :|...
pombe    42 YDQISYQMQKG--HIPGPRFKIPFMGS-----FLD-SMKPTFEKYNAKWQTGPLSCVS--VFHKF 96

  Fly    82 ALMVRDPELIRQVLIKNFNNFLNRFESADAGDPMGALTLPLAKYHHWK--------ESRQCMSQL 138
            .::..:.:|.|::|  |..:::... ..|||.       .:.|:.:|.        |.|:.::.|
pombe    97 VVIASERDLARKIL--NSPSYVQPC-VVDAGK-------KILKHTNWVFLDGRDHIEYRKGLNGL 151

  Fly   139 FTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLP-----LGRMCQLYTTDVTGNLFYSLNV 198
            ||:..:...:.:|........:::|.....|..:.::|     :...|:.:..       |.::.
pombe   152 FTTRALASYLPAQEAVYNKYFKEFLAHSKDDYAQYMIPFRDINVATSCRTFCG-------YYISD 209

  Fly   199 GGLRRGRSEL--ITKTKELFNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMRHLVDDHHE 261
            ..::....|.  ||...||.|.  ..||.|..|     |.|:...||       .||:.:....|
pombe   210 DAIKHIADEYWKITAAMELVNF--PIVLPFTKV-----WYGIQSRKV-------VMRYFMKAAAE 260

  Fly   262 PTKG------------DLINQLQHFQLSRSSN-HYSQHP-----DFVASQAGI----ILLAGFET 304
            ..|.            :.|:::...:..:|.| ..::.|     :|...:..:    .|.|..:.
pombe   261 SRKNMEAGNAPACMMEEWIHEMIETRKYKSENKEGAEKPSVLIREFSDEEISLTFLSFLFASQDA 325

  Fly   305 SSALMGFTLYELAKAPDIQERLRSE---LREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAA 366
            :|:.|.:....||..||:.:::|.|   :|:..|. ..||.|.:..:.|.:.|..|.|||.|...
pombe   326 TSSAMTWLFQLLADHPDVLQKVREEQLRIRKGDID-VPLSLDLMEKMTYTRAVVKECLRLRPPVL 389

  Fly   367 FVNRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHP 431
            .|    .....:.|.:.|  |:.||.......::.|...|.:.:|||..|:|:|:.|.......|
pombe   390 MV----PYRVKKAFPITP--DYTVPKDAMVIPTLYGALHDSKVYPEPETFNPDRWAPNGLAEQSP 448

  Fly   432 MTYIPFGAGPHGCIGSRLGVLQL 454
            ..::.||.|||.|:|.|..|..|
pombe   449 KNWMVFGNGPHVCLGQRYAVNHL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	104/463 (22%)
erg5	NP_593788.2	CypX	57..505	CDD:225035	103/461 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
TreeFam	0	0.000	Not matched by this tool.
	3	3.050