DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	155/509 - (30%)
Similarity:	263/509 - (51%)	Gaps:	41/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLLTIVTLNF---WLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLR-ISFGDLFRQLYADPR 66
            |||||.: |:|   :||:::.|:..||||.|.|...     .|....|: :.:.:|.::.| |..
  Fly     5 LLLLTSL-LSFLLGYLRYRFTYWELRGIPQLRPHFL-----FGHFFRLQSVHYSELLQETY-DAF 62

  Fly    67 NGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNRFESADAGDPMGALTLPLAKYHHWKES 131
            .|.||:.|.::|..|..:|.|.:|::.|||::||||::|  .:..|||:.|....| :...|:..
  Fly    63 RGSAKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDR--RSFHGDPLTANLFNL-QGEEWRNL 124

  Fly   132 RQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTTDVTGNLFYSL 196
            |..:|..||||:|: .|:..:..||..|....:..:|.: ..||.|..:...|||||.|:..:..
  Fly   125 RTKLSPTFTSGKMK-YMFGTVSTVAQQLGGTFDELVGSQ-GAVLELHDLMARYTTDVIGSCAFGT 187

  Fly   197 NVGGLRRGRSELITKTKELFNTNPRKV---------LDFMSVFFLPKWTGVLKPKVFTEDYARYM 252
            ....||..::|.....:.:|..:.|.:         |..::...||  ..:|.|.: |:.:.|.:
  Fly   188 ECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLP--VRILHPDI-TKFFNRIV 249

  Fly   253 RHLVD--DHHEPTKGDLINQLQHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALMGFTLYE 315
            |..|:  :.....:.|.::.|  ..|.|..|......:.:|:||.:..:|||||||:.|.:.|:|
  Fly   250 RETVELRERENIRRNDFMDLL--LDLRRQENGKGLTMEQMAAQAFVFFVAGFETSSSNMSYALFE 312

  Fly   316 LAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSASEGF 380
            |||..|:|::||.|:.::......|:|:.:|.:|||.....|.||.|||.:.:.|    .|||.:
  Fly   313 LAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLRKYPALSSLTR----LASEDY 373

  Fly   381 SLQPHVD----FIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGP 441
            .: |..|    .::..|...:|.:|.:|.|...:|||..|.||||.|:..|..||..::.||.||
  Fly   374 EI-PSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHPTAFLGFGDGP 437

  Fly   442 HGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495
            ..|||.|.|.:|:|:|::.:|:::.......:.::::...::.:|...:.:.|:
  Fly   438 RNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQ 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	138/467 (30%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	142/481 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	8.070