DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t3 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	553	Identity:	129/553 - (23%)
Similarity:	216/553 - (39%)	Gaps:	119/553 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLLL------TIVTLNFWLRHKYD-YFRSRGIPHLPPSSW-----SPMGNLGQLLFLRISFGDL 57
            |.|||      .:..:..|:...|| ..|.|..|..|..||     :.|.|..:.:......|..
Mouse    19 WHLLLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWFWGHLALMKNNEESMQFITHLGHD 83

  Fly    58 FRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVL-----IKNFNNFLNRFESADAGDPMGA 117
            |..::       ...||...   |.|.:..|..|..:|     :......|..|.....||  |.
Mouse    84 FHDVH-------LSWVGPVY---PILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKPWLGD--GL 136

  Fly   118 LTLPLAKYHHWKESRQCMSQLFTSGRMR----------DVMYSQMLDVAS------DLEQYLNRK 166
            |   ::....|...|:.::..|....::          ::|:::...:||      |:.::::..
Mouse   137 L---MSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLDMFEHISLM 198

  Fly   167 LGDRLER-VLPLGRMCQ-------------------------LYTTDVTGNLFYSLNVGGLR-RG 204
            ..|.|:: :..:...||                         ||.     :|.|.|...|.| |.
Mouse   199 TLDSLQKCIFSVDSNCQESDSKYIAAILELSSLVVKRHRQPFLYL-----DLLYYLTADGRRFRK 258

  Fly   205 RSELITKTKELFNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMRHLVDDHHEPTKGDLIN 269
            ..:|:....:......|..|:...|.||.     .|.|..|.|:...:....|:|   .||
Mouse   259 ACDLVHNFTDAVIKERRSTLNTQGVEFLK-----AKAKTKTLDFIDVLLMAEDEH---GKG---- 311

  Fly   270 QLQHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAF 334
                  ||...         :.::|...:..|.:|:::.:.:.||.||:.|:.|||.|.|::|..
Mouse   312 ------LSNED---------IRAEADTFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELL 361

  Fly   335 --ISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSASEGFSLQPHVDFIVPPGMPAY 397
              ..:..:.:|.|..||:|.|...|:|||:|....::|.||...     |.|. ...:|.|....
Mouse   362 RDRDSEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDV-----LLPD-GRAIPKGNICV 420

  Fly   398 ISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHIL 462
            |||.|:|.:...||:|.|::|.||.||..:...|:.:|||.||...|||....:.::|:.:...|
Mouse   421 ISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTL 485

  Fly   463 KQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495
            .::.:...::   |.|..|: .:|.:|..::||
Mouse   486 LRFRILPDDK---EPRRKPE-LILRAEGGLWLR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	115/506 (23%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	118/517 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010