Protein Alignment Cyp6t3 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_610745.1
• Gene: Cyp6t3 / 36318
• FlyBaseID: FBgn0033697
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 128/539 - (23%)
• Similarity: 228/539 - (42%)
• Gaps: 87/539 - (16%)

  Fly     2 LLIWLLLLTIVTLNFWLRHKYDYF----RSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLY 62
            ||::||......|..:||....::    |.|..|..|..:|. :|:||..|.......|..:.|
Human    27 LLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWL-LGHLGMYLPNEAGLQDEKKVL- 89

  Fly    63 ADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKN---------FNNFLNRFESADAGDPMGAL 118
               .|....::.:.....|.|::..|:.|:.:|..:         |..||..:    .||  |.|
Human    90 ---DNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPW----LGD--GLL 145

  Fly   119 TLPLAKYHHWKESRQCMSQLFTSGRMRDVM--YSQMLDVASDLEQYLNRKLGDRLERVLPLGRMC 181
               |:|...|...|:.::..|..    |::  |.::.:.::|:.....|.|.:.....|.:....
Human   146 ---LSKGDKWSRHRRLLTPAFHF----DILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHI 203

  Fly   182 QLYTTDVTGNLFYSLNVGGLRRGRSELITKTKELFNTNPRK------VLDFMSVFFLPKWTGVLK 240
            .|.|.|......:|.| ...:...|:.|:...||...:.|:      .|||  :::.
Human   204 SLMTLDSLQKCVFSYN-SNCQEKMSDYISAIIELSALSVRRQYRLHHYLDF--IYYR-------- 257

  Fly   241 PKVFTEDYARYMRHLVDDHHEPT----------------------KGDLINQLQHFQLSRSSNHY 283
                :.|..|:.:.....||..|                      :|..::.:....|:|..:..
Human   258 ----SADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGK 318

  Fly   284 SQHPDFVASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAF--ISTATLSYDTLM 346
            ....:.:.::|...:..|.:|:|:.:.:.|:.|||.|:.||:.|.|::|..  .....|.:|.|.
Human   319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLT 383

  Fly   347 TLPYLKMVCLEALRLYPAAAFVNRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWP 411
            .||:..|...|:||.||....|:|:||    |...|..  ..|:|.|:...:||.|.|.:...||
Human   384 QLPFTTMCIKESLRQYPPVTLVSRQCT----EDIKLPD--GRIIPKGIICLVSIYGTHHNPTVWP 442

  Fly   412 EPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSE 476
            :..|::|.||.|:..:...|:.|:||.|||..|||....:.:|::.:...|.::.: :.:|| .:
Human   443 DSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL-SVDRT-RK 505

  Fly   477 IRFNPKSFMLESENEIYLR 495
            :|..|: .:|.:||.::|:
Human   506 VRRKPE-LILRTENGLWLK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	CYP6-like	68..493	CDD:410679	108/465 (23%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	111/481 (23%)