DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and CYP3A7-CYP3A51P

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001243426.2	Gene:	CYP3A7-CYP3A51P / 100861540	HGNCID:	51504	Length:	535	Species:	Homo sapiens

Alignment Length:	532	Identity:	145/532 - (27%)
Similarity:	251/532 - (47%)	Gaps:	67/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLL-LTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPRNG 68
            |||| ::::.|..:....:..|:..|||     ..:|:..||..|..|..:.....:.|...|
Human    12 WLLLAVSLILLYLYGTRTHGLFKKLGIP-----GPTPLPFLGNALSFRKGYWTFDMECYKKYR-- 69

  Fly    69 QAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGALTLPLAKYHHWKESR 132
              |:.|.:..|.|.|.:.||::|:.||:|. ::.|.||......|....|::  :|:...||..|
Human    70 --KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAIS--IAEDEEWKRIR 130

  Fly   133 QCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLP--LGRMCQLYTTDVTGNLFYS 195
            ..:|..||||:::     :|:.:.:.....|.|.|....|...|  |..:...|:.||..:..:.
Human   131 SLLSPTFTSGKLK-----EMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFG 190

  Fly   196 LNVGGLRRGRSELITKTKELFNTNPRKVLD--FMSVFFLPKWTGVLK-------PKVFTEDYARY 251
            :::..|...:...:..||:|...||   ||  .:|:...|..|.:|:       |:.......:.
Human   191 VSIDSLNNPQDPFVENTKKLLRFNP---LDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252

  Fly   252 MRHLVDDHHEPTKGDLINQLQHFQLSRSSNHYSQHPDF----VASQAGIILLAGFETSSALMGFT 312
            ::.:.:...:.|:...::.||....|::|.....|...    :.:|:.|.:.||:||:|:::.|.
Human   253 VKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFI 317

  Fly   313 LYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSAS 377
            :||||..||:|::::.|:.....:.|..:|||::.|.||.||..|.|||:|.|..:.|.|.....
Human   318 IYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVE 382

  Fly   378 EGFSLQPHVDFIVPPG----MPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFG 438
            ..       ...:|.|    :|:|:    ||.|.::|.||..|.||||..:...:|.|..|.|||
Human   383 IN-------GMFIPKGVVVMIPSYV----LHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFG 436

  Fly   439 AGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERT--VSEIRF-----NPKSFMLESENE----- 491
            :||..|||.|..::.:||.:|.:|:.:..:.|:.|  ..::||     ..|..:|::|:.
Human   437 SGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETFV 501

  Fly   492 ----IYLRFCRS 499
                |::.|.||
Human   502 DMEPIHMDFLRS 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	130/478 (27%)
CYP3A7-CYP3A51P	NP_001243426.2	p450	39..492	CDD:278495	131/482 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820