DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp2c69

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001097995.1	Gene:	Cyp2c69 / 100043108	MGIID:	3721049	Length:	491	Species:	Mus musculus

Alignment Length:	511	Identity:	105/511 - (20%)
Similarity:	196/511 - (38%)	Gaps:	106/511 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLIWLLLLTIVTLNFWLRHKYDYFRSRGI-PHLPPSSWSPM---GN--------LGQLL--FLRI 52
            :::.|.|..::.|:.|        |.|.. .:|||.. :|:   ||        :||.|  |.:
Mouse     5 VVLVLCLSFMLLLSLW--------RQRSARRNLPPGP-TPLPIIGNYHLIDMKDIGQCLTNFSK- 59

  Fly    53 SFGDLFRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNR-----FESADAG 112
            ::|.:|.               .:....|.:::...|.|::.||.:...|..|     |:....|
Mouse    60 TYGPVFT---------------LYFGSQPIVVLHGYEAIKEALIDHGEVFSGRGSFPFFDKVSKG 109

  Fly   113 DPMGALTLPLAKYHH---WKESRQCMSQLFTSGRMRDV------MYSQMLDVASDLEQYLNRKLG 168
            ..:|        :.|   ||.:|     :||...:|::      :.:::.:.|..|.:.|.:..|
Mouse   110 KGIG--------FSHGNVWKATR-----VFTVNTLRNLAMGKRTIENKVQEEAQWLMKELKKTNG 161

  Fly   169 DRLERVLPLG-RMCQLYTTDVTGNL-------FYSLNVGGLRRGRSELITKTKELFNTNPRKVLD 225
            ...:....:| ..|.:..:.|..|.       |.|| :|.:......|.:...::||..| .::|
Mouse   162 SPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSL-IGKVNECTEILSSPGCQIFNAVP-ILID 224

  Fly   226 FM----SVFFLPKWTGVLKPKVFTEDYARYMRHLVDDHHEPTKGDLINQ---LQHFQLSRSSNHY 283
            :.    :.||        |...:.:.   |:...:.:|.|..  |:.|.   :.:|.:.|..:..
Mouse   225 YCPGRHNKFF--------KNHTWIKS---YLLEKIKEHEESL--DVTNPRDFIDYFLIQRRQDKG 276

  Fly   284 SQHPDF----VASQAGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDT 344
            .:|.::    :|:....::..|.||.|:.|.|.|..|.|...|..:::.|:........:.....
Mouse   277 IEHMEYTIEHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQD 341

  Fly   345 LMTLPYLKMVCLEALRLYPAAAFVNRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERF 409
            ...:||...:..|..|      :|:...||...|........::.:|.|.....|:..:..|...
Mouse   342 RKHMPYTNAMVHEVQR------YVDLGPTSLVHEVTCDTKFRNYFIPKGTQVMTSLSSVLHDSTE 400

  Fly   410 WPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQY 465
            :|.|.||||..|..:.........::||.||...|:|..|..::|.|.:..||:.:
Mouse   401 FPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLTTILQNF 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	98/478 (21%)
Cyp2c69	NP_001097995.1	p450	30..487	CDD:278495	98/478 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010