DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t3 and Cyp3a59

DIOPT Version :9

Sequence 1:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001098630.1	Gene:	Cyp3a59 / 100041449	MGIID:	3769707	Length:	503	Species:	Mus musculus

Alignment Length:	517	Identity:	137/517 - (26%)
Similarity:	237/517 - (45%)	Gaps:	62/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLLLLTIVTLNFWLRHKYDY--FRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFR------QL 61
            |:||:|.:.. |::...|.:  |:..|||...|   .|:            ||.:|.      :.
Mouse    12 WVLLVTSLVF-FYIYGTYSHGLFKKLGIPGPKP---LPL------------FGTIFNYFDGMWKF 60

  Fly    62 YADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGAL--TLPLA 123
            ..|......||.||::...|.|.:.|||:|:.||:|. ::.|.||    ....|:|.|  ::.::
Mouse    61 DEDCYKKYGKIWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNR----PTLGPVGFLKKSITIS 121

  Fly   124 KYHHWKESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGR--MCQLYTT 186
            :...||..|..:|..||||:::     :|..:.......|.|.|....|:..|:..  :...|:.
Mouse   122 EDEEWKRLRTLLSPTFTSGKLK-----EMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSM 181

  Fly   187 DVTGNLFYSLNVGGLRRGRSELITKTKELFNTNPRKVLD--FMSVFFLPKWTGV---LKPKVFTE 246
            ||.....:.:|:..|...::..:.|||::...   |:.|  .:|....|..|.:   |...:|..
Mouse   182 DVITGTSFGVNIDSLNNPQNPFVQKTKKILKF---KIFDPFLLSTILFPFLTPIYEMLNLSIFPR 243

  Fly   247 D----YARYMRHLVDDH---HEPTKGDLINQLQHFQLSRSSNHYSQHPDF-VASQAGIILLAGFE 303
            |    :.::::.:..:.   .:..:.|.:..:.:.|.|:.........|. :|:||.|.:..|::
Mouse   244 DSMNFFKKFVKRMKKERLASKQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAVIFIFGGYD 308

  Fly   304 TSSALMGFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFV 368
            .:|..:...:||||..||:|::|:.|:.....:.|.::||.||.:.||.||..|:|||||.|..:
Mouse   309 ATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPTAIRL 373

  Fly   369 NRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMT 433
            .|.........       ...:|.|....|.|..|||:..:||||..|.|.||..|...:|.|..
Mouse   374 ERVSKKDVEIN-------GVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYI 431

  Fly   434 YIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495
            |:|||.||..|:..|..::.:||.::.:|:.:.|:.||.|...::.: :..:.:.|..|.|:
Mouse   432 YMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKIS-REPVFQPEKPIILK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	124/475 (26%)
Cyp3a59	NP_001098630.1	p450	39..493	CDD:278495	128/489 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820