Protein Alignment Cyp6g2 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_610744.1
• Gene: Cyp6g2 / 36317
• FlyBaseID: FBgn0033696
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 147/564 - (26%)
• Similarity: 242/564 - (42%)
• Gaps: 121/564 - (21%)

  Fly     3 LVLLILVASLIGIAFLA-LQQHYSYWRRMGVREIRPK--WIVGNLMGLLNMRMSPAEFISQLYNH 64
            |:||::|.|.:....|| ....|:..||:......||  |..|:| ||:    :|.|  ..|.|.
Human    20 LLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHL-GLI----TPTE--EGLKNS 77

  Fly    65 PDAENEPFVGIHVFHKPA---LLLRDPEMVRNILVKDFAGFSNRYSSSDPKGDPLGSQNIF--FL 124
            .........|..|:..|.   ::|..|:.:|:|        :|..::..||      .|:|  ||
Human    78 TQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSI--------TNASAAIAPK------DNLFIRFL 128

  Fly   125 K-----------NPAWKEVRLKLSPFFTGNRLKQMFPLI-EEVGASLD--AHLRQQPLHNERMRC 175
            |           ...|...|..|:|.|..|.||....:. :.....||  .||..:  .:.|:..
Human   129 KPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASE--GSSRLDM 191

  Fly   176 FDLEAKELCALYTTDVIATVAYGVSANSFTDPKCEFR--RHGRSVFEF---------NLLRAAEF 229
            |     |..:|.|.|.:....:     || |..|:.|  .:..::.|.         ::|:..:|
Human   192 F-----EHISLMTLDSLQKCIF-----SF-DSHCQERPSEYIATILELSALVEKRSQHILQHMDF 245

  Fly   230 TLVFFLPHLVPFVRFKVVPAEATRFLRKTINYVMSER--------------EKSGQKRNDLIDIL 280
              :::|.|  ...||.    .|.|.:....:.|:.||              :|:..|..|.||:|
Human   246 --LYYLSH--DGRRFH----RACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVL 302

  Fly   281 IEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFFTAGFESSSSTMAFAMYELAKDTDVQQRLREE 345
            :       |:|.   :|......:.:.|:|..|...|.::::|.:::.:|.||:..:.|:|.|:|
Human   303 L-------LSKD---EDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQE 357

  Fly   346 IKDALVE-SGGQVTLKMIESLEFMQMILLEVLRMYPPLPFLDRECT------SGRDYSLAPFHKK 403
            :::.|.: ...::....:..|.|:.|.:.|.||::||.||:.|.||      .||
Human   358 VQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGR---------- 412

  Fly   404 FVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENRKLHTPYTYMPFGLGPHGCIGERFGYL 468
             |:|||:...|....:|.:|..:|.|..:.|.||.|||.|..:|..::||..||..|||:.|...
Human   413 -VIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMA 476

  Fly   469 QAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQAKGGIHLRL 512
            :.||.|. |:..|.....:.|..|.:|:   :|.:|:||:.||:
Human   477 EMKVVLA-LMLLHFRFLPDHTEPRRKLE---LIMRAEGGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g2	NP_610744.1	CYP6-like	69..509	CDD:410679	124/490 (25%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	126/500 (25%)