Protein Alignment Cyp6g2 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_610744.1
• Gene: Cyp6g2 / 36317
• FlyBaseID: FBgn0033696
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 134/562 - (23%)
• Similarity: 242/562 - (43%)
• Gaps: 118/562 - (20%)

  Fly     3 LVLLILVASLIGIAFLAL-QQHYSYWRRMGV--REIRPKWIVGNLMGLLNMRMSPAEFISQLYNH 64
            |.||..:..|: :.||.| :..|...||:..  :..|..|::|:| |:            .|.|.
Human    29 LFLLFFLFRLL-LRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHL-GM------------YLPNE 79

  Fly    65 PDAENEPFVGIHVFH---------KPALLLRDPEMVRNILVKDFAGFSNRYSSSDPKGD------ 114
            ...::|..|..::.|         .|.|:|..|:.::.:|     |.|   ::..||.|
Human    80 AGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLL-----GAS---AAIAPKDDLFYGFL 136

  Fly   115 -PLGSQNIFFLKNPAWKEVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDL 178
             |.....:...|...|...|..|:|.|..:.||....:..:....:.|..|    |........|
Human   137 KPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWR----HLAEGSAVSL 197

  Fly   179 EAKELCALYTTDVIATVAYGVSANSFTDPKCEFRR--HGRSVFEFNLLRAAEFTLVFFLPHLVPF 241
            :..|..:|.|.|.:....:..::|      |:.:.  :..::.|   |.|......:.|.|.:.|
Human   198 DMFEHISLMTLDSLQKCVFSYNSN------CQEKMSDYISAIIE---LSALSVRRQYRLHHYLDF 253

  Fly   242 VRFKVVPAEATRF------LRKTINYVMSEREKSGQKRN-------------DLIDILIEFRRST 287
            :.::  .|:..||      :......|:.||.::.:::.             |.||:|:
Human   254 IYYR--SADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLL------ 310

  Fly   288 QLAKASGIKDQFVFEGDILVAQAVLFFTAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVE 352
             ||:....|:  :.:.||. |:|..|...|.:::||.:::.::.|||..:.|::.||||::  |.
Human   311 -LARDEDGKE--LSDEDIR-AEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQE--VM 369

  Fly   353 SGGQVTLKMIE-----SLEFMQMILLEVLRMYPPLPFLDRECT------SGRDYSLAPFHKKFVV 406
            .|.:  |:.:|     .|.|..|.:.|.||.|||:..:.|:||      .||           ::
Human   370 KGRE--LEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGR-----------II 421

  Fly   407 PKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENRKLHTPYTYMPFGLGPHGCIGERFGYLQAK 471
            |||:...:..|..|.:|..:|..:.:.|.||.|:|.:..:|..|:||..||..|||:.|...:.:
Human   422 PKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELR 486

  Fly   472 VGL-VNLLRNHMITTSERTPHRMQLDPKAIITQAKGGIHLRL 512
            |.: :.|||..:  :.:|| .:::..|: :|.:.:.|:.|::
Human   487 VVVALTLLRFRL--SVDRT-RKVRRKPE-LILRTENGLWLKV 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g2	NP_610744.1	CYP6-like	69..509	CDD:410679	116/488 (24%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	116/492 (24%)