Protein Alignment Cyp6g2 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_610744.1
• Gene: Cyp6g2 / 36317
• FlyBaseID: FBgn0033696
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 129/505 - (25%)
• Similarity: 218/505 - (43%)
• Gaps: 84/505 - (16%)

  Fly     6 LILVASLIGIAFLALQQHYSYWRRMGVREI----RPKWIVGNLMGLLNMRMSPAEFISQLYNHPD 66
            |:|:.|.:.:|| .|...:.:..|.....|    ||.:::|:|.............:..::....
Human     5 LLLLGSAVLLAF-GLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWA 68

  Fly    67 AENEPFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSSSDPK---------GDPLGSQNIF 122
            .:..|.|.::||||.::::..||.|:..|:      |.:| :.|.|         |:.|..|.:.
Human    69 KKYGPVVRVNVFHKTSVIVTSPESVKKFLM------STKY-NKDSKMYRALQTVFGERLFGQGLV 126

  Fly   123 FLKN-PAWKEVRLKLSPFFTGNRLKQMF--------PLIEEVGASLDAHLRQQPLHNERMRCFDL 178
            ...| ..|.:.|..:...|:.:.|..:.        .|:|.:.|..|.   |.|:..:.|
Human   127 SECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADG---QTPVSMQDM----- 183

  Fly   179 EAKELCALYTT-DVIATVAYGVSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPFV 242
                  ..||. |::|..|:|:..:.....:....:..:.:.|.  :.|:..||..|||.....:
Human   184 ------LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEG--ITASRNTLAKFLPGKRKQL 240

  Fly   243 RFKVVPAEATRFLRKTINYVMSEREKSGQKRNDLI--DILIEFRRSTQLAKA-SGIKDQFVFEGD 304
            |   ...|:.||||: :.....:|.:...||.:.:  |||      ||:.|| .|.:|.   ||
Human   241 R---EVRESIRFLRQ-VGRDWVQRRREALKRGEEVPADIL------TQILKAEEGAQDD---EG- 291

  Fly   305 ILVAQAVLFFTAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQ 369
             |:...|.||.||.|:|::.:||.:.||::..::..||:.|: |.::.|...:..:.:..|:::.
Human   292 -LLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEV-DEVIGSKRYLDFEDLGRLQYLS 354

  Fly   370 MILLEVLRMYPP----LPFLDRE-CTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQP 429
            .:|.|.||:|||    ...|:.| ...|           ..||...|:....|.:.....||..|
Human   355 QVLKESLRLYPPAWGTFRLLEEETLIDG-----------VRVPGNTPLLFSTYVMGRMDTYFEDP 408

  Fly   430 RKFLPERFSPENRKLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLR 479
            ..|.|:||.|...|  ..:||.||.||...|||::|..::.||.:..||:
Human   409 LTFNPDRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g2	NP_610744.1	CYP6-like	69..509	CDD:410679	117/438 (27%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	117/448 (26%)