Protein Alignment Cyp6g1 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_610743.2
• Gene: Cyp6g1 / 36316
• FlyBaseID: FBgn0025454
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 169/524 - (32%)
• Similarity: 279/524 - (53%)
• Gaps: 57/524 - (10%)

  Fly     5 EVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMEN--SFGMHLSEIYNDPR 67
            |...:|..:||.||.:...:|..:::.|||...|.|.:|.  ::|.:..  :|....:|.|.:
Human    10 ETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGT--ILFYLRGLWNFDRECNEKYGE-- 70

  Fly    68 LKDEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLGY--NNLFFVRDAH 129
                 :.|:|...:|.|:|.|.::||::|:|: ::.|.|:.    |.| |:|:  :.|.|..|..
Human    71 -----MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM----PLG-PMGFLKSALSFAEDEE 125

  Fly   130 WKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATI 194
            ||.|||.|:|.|||.|.|:|..::.:.|..|..:|::..| ||.|.  .:|:....::.|.|...
Human   126 WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAE-NSKSI--NLKDFFGAYTMDVITGT 187

  Fly   195 AFGIRANSLENPNAEFRNYGRKMFTFTVARAKDFFVAFFLPKLVSL----------MRIQFFTAD 249
            .||:..:||.||...|....:|:...      ||...|.|  |:||          :.|..|..|
Human   188 LFGVNLDSLNNPQDPFLKNMKKLLKL------DFLDPFLL--LISLFPFLTPVFEALNIGLFPKD 244

  Fly   250 FSHFMRSTIGHVMEERERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGF 314
            .:||::::|..:.|.|.:.  .:...:|....:.....::.:|.|.|.:...||||:.:...|.:
Human   245 VTHFLKNSIERMKESRLKD--KQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAY 307

  Fly   315 ETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLP 379
            :|:|:|:.|.:||:|.||::|::|::|| :|::.....::|:.:..:|||.|||:|.||::||:.
Human   308 DTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS 371

  Fly   380 FLDREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPE-RFSPANRKNI 443
            .:.|..:.     |:.:...:   :..|..|.:|||||||||||||.|.:|.|| |||..|:.:|
Human   372 RVTRVCKK-----DIEINGVF---IPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSI 428

  Fly   444 VAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFD--PKGFVLQADGGI 506
            ....|.|||:||.||||.|..|...||.::..|:|.|.:.|:.|...:|.|  |   :||.:..|
Human   429 DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP---ILQPEKPI 490

  Fly   507 HLEI 510
            .|::
Human   491 VLKV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_610743.2	CYP6-like	69..507	CDD:410679	150/453 (33%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	152/462 (33%)