DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6g1 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	524	Identity:	169/524 - (32%)
Similarity:	279/524 - (53%)	Gaps:	57/524 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMEN--SFGMHLSEIYNDPR 67
            |...:|..:||.||.:...:|..:::.|||...|.|.:|.  ::|.:..  :|....:|.|.:
Human    10 ETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGT--ILFYLRGLWNFDRECNEKYGE-- 70

  Fly    68 LKDEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLGY--NNLFFVRDAH 129
                 :.|:|...:|.|:|.|.::||::|:|: ::.|.|:.    |.| |:|:  :.|.|..|..
Human    71 -----MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM----PLG-PMGFLKSALSFAEDEE 125

  Fly   130 WKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATI 194
            ||.|||.|:|.|||.|.|:|..::.:.|..|..:|::..| ||.|.  .:|:....::.|.|...
Human   126 WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAE-NSKSI--NLKDFFGAYTMDVITGT 187

  Fly   195 AFGIRANSLENPNAEFRNYGRKMFTFTVARAKDFFVAFFLPKLVSL----------MRIQFFTAD 249
            .||:..:||.||...|....:|:...      ||...|.|  |:||          :.|..|..|
Human   188 LFGVNLDSLNNPQDPFLKNMKKLLKL------DFLDPFLL--LISLFPFLTPVFEALNIGLFPKD 244

  Fly   250 FSHFMRSTIGHVMEERERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGF 314
            .:||::::|..:.|.|.:.  .:...:|....:.....::.:|.|.|.:...||||:.:...|.:
Human   245 VTHFLKNSIERMKESRLKD--KQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAY 307

  Fly   315 ETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLP 379
            :|:|:|:.|.:||:|.||::|::|::|| :|::.....::|:.:..:|||.|||:|.||::||:.
Human   308 DTTSTTLPFIMYELATHPDVQQKLQEEI-DAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS 371

  Fly   380 FLDREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPE-RFSPANRKNI 443
            .:.|..:.     |:.:...:   :..|..|.:|||||||||||||.|.:|.|| |||..|:.:|
Human   372 RVTRVCKK-----DIEINGVF---IPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSI 428

  Fly   444 VAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFD--PKGFVLQADGGI 506
            ....|.|||:||.||||.|..|...||.::..|:|.|.:.|:.|...:|.|  |   :||.:..|
Human   429 DLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP---ILQPEKPI 490

  Fly   507 HLEI 510
            .|::
Human   491 VLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	153/467 (33%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	160/493 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720