DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6g1 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	530	Identity:	156/530 - (29%)
Similarity:	254/530 - (47%)	Gaps:	73/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TEVLFVVVAALVALY-TWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPR 67
            |..|...:|||:.:| :|   .|.|:::.|||.....|..| |.:.:|    .|.|:.::  |..
Zfish     7 TWTLLAFLAALLVIYGSW---PHRYFKKLGIPGPKAIPFFG-TMLRYK----DGFHVFDM--DCF 61

  Fly    68 LKDEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLG---YNNLFFVRDA 128
            .|...:.|||...:|.|.|.|..:||::|||: ::.|.||      ....|.   |:.:....|.
Zfish    62 EKYGRIWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNR------RNFRLNGALYDAVSIAEDD 120

  Fly   129 HWKGIRTKLTPVFTSGKVKQMYTLMQE--------IGKDLELALQRRGEKNSGSFITEIKEICAQ 185
            .|:.||:.|:|.||||::|:|:.:|::        :||     ..:|||.      .:|||....
Zfish   121 DWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGK-----TAKRGES------ADIKEFFGA 174

  Fly   186 FSTDSIATIAFGIRANSLENPNAEFRNYGRKMFTFTVARAKDFFVAF--FLPKLVSLMRIQFFTA 248
            :|.|.:.:.||.:..:||.||...|....:||..|.:.......:||  |:..::..|....|..
Zfish   175 YSMDVVTSTAFSVDIDSLNNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPT 239

  Fly   249 DFSHFMRSTIGHVMEERERSGLLRN------DLIDVLVSLRKEAAAEPSKPHYAK--NQDFLVAQ 305
            ..:.|..:.:..:..:|:...:.::      |.:.::|..:.....:....|..|  :...:::|
Zfish   240 SVTDFFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQ 304

  Fly   306 AGVFFTAGFETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDE 370
            :.:|..||:||||||:||..|.:|.:||..|:|::||:|.. .....:.||.:.|::||...:.|
Zfish   305 SMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETF-PNQAPVDYETLMSMDYLDAALSE 368

  Fly   371 VLRMYPVLPFLDREYESVEGQPDLSLKPFYDYTLE-NG------TPVFIPIYALHHDPKYWTNPS 428
            .||::||...|:|..:.               |:| ||      ..|.:|.||||.||.||:.|.
Zfish   369 SLRLFPVAARLERVCKK---------------TVEINGLLIPKDLVVMVPTYALHRDPDYWSEPE 418

  Fly   429 QFDPERFSPANRKNIVAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKF 493
            .|.||||:..|:::|....|.|||.||.||||.|...:..||.:|.:|:...|..|:.|...::.
Zfish   419 SFKPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLEL 483

  Fly   494 DPKGFVLQAD 503
            ...|.:...|
Zfish   484 GFNGLLSPKD 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	140/477 (29%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	145/499 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820