DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp3a41a

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_059092.2	Gene:	Cyp3a41a / 53973	MGIID:	1858451	Length:	504	Species:	Mus musculus

Alignment Length:	525	Identity:	174/525 - (33%)
Similarity:	272/525 - (51%)	Gaps:	57/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TEVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRL 68
            |.||..::  ||.||.:..|.|..::::|||...|.|.:|.....:|....|.|...|.|.
Mouse    11 TWVLLAII--LVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYKGLWKFDMECYEKYG---- 69

  Fly    69 KDEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLGYNN--LFFVRDAHW 130
               ...|::....|..:|.|.|:||::|:|: |:.|.||     ....|:|..:  :...:|..|
Mouse    70 ---KTWGLFDGQMPLFVITDPEMIKNVLVKECFSVFTNR-----REFGPVGIMSKAISISKDEEW 126

  Fly   131 KGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIA 195
            |..|..|:|.|||||:|:|:.::::.|..|...|.:..||  |..:| :|::...:|.|.|.:.:
Mouse   127 KRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEK--GKPVT-MKDVLGAYSIDVITSTS 188

  Fly   196 FGIRANSLENPNAEFRNYGRKMFTFTVARAK-----DFF-------VAF-FLPKLVSLMRIQFFT 247
            ||:..:||.||...|           |.:||     |||       |.| ||..:..::.|..|.
Mouse   189 FGVNVDSLNNPEDPF-----------VEKAKGILRVDFFDPLVFSVVLFPFLTPVYEMLNICMFP 242

  Fly   248 ADFSHFMRSTIGHVMEER-ERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFT 311
            .|...|.:..:..:.|.| :.....|.|.:.::::....:..:.|  |.|.:...:.||:.||..
Mouse   243 KDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKDS--HKALSDMEITAQSIVFIF 305

  Fly   312 AGFETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYP 376
            ||:||:|||:||.||.:|.||::||:|::||:|.| ......:|:.:..:|||.||::|.||:||
Mouse   306 AGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETL-PNKAPPTYDTVMEMEYLDMVLNETLRLYP 369

  Fly   377 VLPFLDREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRK 441
            :...|:|..:.     |:.|...|   :..|:.|.||.|||||||::|..|.:|.|||||..|:.
Mouse   370 IGNRLERFCKK-----DVELNGVY---IPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKG 426

  Fly   442 NIVAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGI 506
            :|....|.|||.||.||||.|...:..||.|..:::|.|.:.|:.|...:|...:| :||.:..|
Mouse   427 SIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQG-LLQPEKPI 490

  Fly   507 HLEIV 511
            .|::|
Mouse   491 VLKVV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	155/468 (33%)
Cyp3a41a	NP_059092.2	p450	39..494	CDD:278495	162/492 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720