DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	512	Identity:	148/512 - (28%)
Similarity:	257/512 - (50%)	Gaps:	56/512 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGN----TKVVFKMENSFGMHLSEIYNDP 66
            ::|:|:..|.....|   .|.::::.|||...|.|..|.    ||..|    :|.|..::.|.
Zfish    13 LVFLVITLLYMYGVW---PHGFFKKLGIPGPRPWPFFGTFLSYTKGFF----NFDMECAKKYG-- 68

  Fly    67 RLKDEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHN-RYARCDPHGDPLGYNNLFFVRDAH 129
                 .|.|||....|.|::.|:|:||:|::|: ::.|.| |....|..| ||. :.:..|:|..
Zfish    69 -----KVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAG-PLA-DGISAVKDER 126

  Fly   130 WKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATI 194
            ||.||..|:|.||||::|:::.:...........:|:|..:..    .:|||:.|.:|.|.:.:.
Zfish   127 WKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQP----VKIKEVVAPYSLDVVTSS 187

  Fly   195 AFGIRANSLENPNAEFRNYGRKMFTFTVARAKDFFVAFF--LPKLVSLMRIQFFTADFSHFMRST 257
            :|.:..:|:.||:..|....:....|::......|:..|  :..|:..|.|..|:....:|..:.
Zfish   188 SFSVDIDSINNPDDPFVTNIKNFLKFSLFSPLILFLTLFPSIANLLGKMGISVFSRSIMNFFYTA 252

  Fly   258 IGHVMEERERSG--------LLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGF 314
            :..:.:|.:.|.        :::|.:.|   ...|:..:|  :|........:::|:.:|...|:
Zfish   253 LRKIKDEHKDSNGRVDFLRLMIQNQIPD---DQAKDTTSE--QPVKGLTDHEILSQSFIFILGGY 312

  Fly   315 ETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLP 379
            ||:|:|:||.|:.:|.:|:..::|.:||::.. .....:||:.:..::||.|.::|.:|:.|..|
Zfish   313 ETTSTTLSFLLHNLATNPDCLEKLVEEIDKNF-PLDTPISYDALMKMDYLEMSINESMRLLPTAP 376

  Fly   380 FLDRE-YESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNI 443
            .|:|. .::||         ....|:...|.|.||.|.|:.||:.|.:|.:|.||||||.|:...
Zfish   377 RLERVCKKTVE---------LNGITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEF 432

  Fly   444 VAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMK----FDPK 496
            :..|:.|||.||.||||.|..|:..||.:|.||:|.|:..|:.|...::    |.||
Zfish   433 LQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLELTPVFQPK 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	133/458 (29%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	141/484 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8421
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720