DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	175/515 - (33%)
Similarity:	274/515 - (53%)	Gaps:	24/515 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLTEVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYND 65
            |:|..::.|:::.||..   .:|.|.||||:|||:....|:.||.|   ...|.  .|::||:.|
  Fly     1 MLLLALIVVILSLLVFA---ARRRHGYWQRRGIPHDEVHPLFGNIK---DWPNK--RHIAEIFRD 57

  Fly    66 PRLK----DEAVVGIYSMNKPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVR 126
            ...|    |....|.:.......::.|:||:|.:||||||.|.||....:...|||. ..||.:.
  Fly    58 YYFKYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLS-ATLFSIE 121

  Fly   127 DAHWKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSI 191
            ...|:.:|.||||.|||||:|.|:.::.::|::::...:.:...:.|. :.|:.::.|:::.|.|
  Fly   122 GQKWRHLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTAADRGQ-VLEVVDLVARYTADVI 185

  Fly   192 ATIAFGIRANSLENPNAEFRNYGRKMFT-FTVARAKDFFVAFFLPKLVSLMRIQFFTADFSHFMR 255
            ...|||:..|||.:|.|||.:.|::..| .......|.|: |..|||...:|::....:...|..
  Fly   186 GNCAFGLNCNSLYDPKAEFVSIGKRAITEHRYGNMLDIFL-FGFPKLSRRLRLKLNIQEAEDFYT 249

  Fly   256 STIGHVMEERERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETSSST 320
            ..:...::.|.|:...|||.:|.|:.:.|...:..|:.....|:  |:|||.:||.|||||||:|
  Fly   250 KIVRETIDYRLRTKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNE--LLAQAFIFFVAGFETSSTT 312

  Fly   321 MSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFLDREY 385
            |.|||||:|::.::|.:||:||.....:.....:||.|:.::||..||.|.||.||||..|.|..
  Fly   313 MGFALYELARNQDVQDKLREEIGNVFGKHNKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMT 377

  Fly   386 ESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAMAYQP 450
            ::.....|..      |.:..||.|.||...:|:||..:..|..|.||||:........:..:.|
  Fly   378 DTDFSPEDPK------YFIAKGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAARPSCTWLP 436

  Fly   451 FGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLEI 510
            ||.||.||||.|.|::|:.:||..|::.:.......|...||...|..::.|:.||||::
  Fly   437 FGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHLKV 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	154/456 (34%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	153/457 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461093
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800