DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp317a1

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001286435.1	Gene:	Cyp317a1 / 36667	FlyBaseID:	FBgn0033982	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	147/536 - (27%)
Similarity:	252/536 - (47%)	Gaps:	64/536 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLFVVVAALV-------ALYTWFQRNHSYWQRKGIPYIPPT---PIIGNTKV-VFKMENSFGMHL 59
            ::|:::..||       .:...:||:  ||:...||:..|.   |||..... ....|.....|.
  Fly     3 IIFLIIGLLVLGLLVLLIIAARYQRD--YWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHY 65

  Fly    60 SEIYNDPRLKDEA-VVGIYSMNKPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLF 123
            |.||.  :.|... ..|.|::.:|..:|.|.|||:.|:||||..|::|...|:...|||. .:|:
  Fly    66 SAIYK--KFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKSDPLS-GDLY 127

  Fly   124 FVRDAHWKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFST 188
            .:|...||.:|.||.|.....::..:|..:.|..:.|.|.:.........|.: .|::|..::..
  Fly   128 ALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTV-HIQKIMRRYVL 191

  Fly   189 DSIATIAFGIRANSLEN-PNAEFRNYGRKMFTFTVARAKDFFVAFFLPKLVSLMRIQFFTADFSH 252
            .|:|...||:.|...:. |..:|    .:|....:...|..:       |::||.|:|  .:|..
  Fly   192 SSLAKCVFGLNAEQRKTYPLEDF----EQMTELALNSHKHGY-------LMNLMMIRF--PNFCR 243

  Fly   253 FMR-------------STIGHVMEERERSGLLRNDLIDVLVSLRK----EAAAEPSKPHYAKNQD 300
            .:|             ..:..::|:||.||..:.|.:.:|:.::.    ....|..|...|..|:
  Fly   244 MLRMRRTPKQAEEYFIKLLTSIVEQRETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQN 308

  Fly   301 FLVAQAGVFFTAGFETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLA 365
            .|.|.|.||..||:|.:::|:|:.|||:|.|||:|.|:|:|:.:|:....|.:::|.|:||.::.
  Fly   309 ELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMG 373

  Fly   366 MVVDEVLRMYPVLPFLDREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQF 430
            .|::|.|||:|:.|::.|...:....||   .|  .|.|.....:.||.:|:||||..:.:|.:|
  Fly   374 QVINETLRMHPITPYILRRTLNDYAVPD---HP--KYILVKELFLIIPTHAIHHDPDIYPDPEEF 433

  Fly   431 DPERFSPANRKNIVAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDP 495
            .|:|:|...........:..||.|..:|||.:...||.:|.|..||..:          :...:.
  Fly   434 KPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEY----------EFSLNT 488

  Fly   496 KGFVLQADGGIHLEIV 511
            :..::..:.||.|.::
  Fly   489 RKPLINLEDGIALTLM 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	132/470 (28%)
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	129/448 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461097
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900