DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp6a23

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	192/524 - (36%)
Similarity:	282/524 - (53%)	Gaps:	48/524 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLFVVVAALVALYTWF-QRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRLK 69
            :|..::|.||:|..:. :|.|.||||:|||:..|.||.||.|...|..     |::.|:.|...|
  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKR-----HIAMIFRDYYTK 62

  Fly    70 DEAVV----GIYSMNKPGLIIRDIELIKSILIKDFNRFHNR---YARCDPHGDPLGYNNLFFVRD 127
            .:..|    |.|.......:|.|:||:|.:||||||.|.||   |...|   |||. ..||.:..
  Fly    63 YKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEID---DPLS-ATLFSIEG 123

  Fly   128 AHWKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIA 192
            ..|:.:|.||||.|||||:|.|:.::.::|:::|.....:.....|. :.||.::.|:::.|.|.
  Fly   124 QKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQ-VLEIVDLVARYTADVIG 187

  Fly   193 TIAFGIRANSLENPNAEF----------RNYGRKMFTFTVARAKDFFVAFFLPKLVSLMRIQFFT 247
            ..|||:..|||:||||||          |.||..:         ||.: |..|||...:|::...
  Fly   188 NCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLL---------DFLI-FGFPKLSRRLRLKLNV 242

  Fly   248 ADFSHFMRSTIGHVMEERERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTA 312
            .|...|..|.:.:.::.|.|:...|:|.:|.|:.:.::..|..::...:.|:  ::|||.:||.|
  Fly   243 QDVEDFYTSIVRNTIDYRLRTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNE--ILAQAFIFFVA 305

  Fly   313 GFETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPV 377
            ||||||:||.|||||:|...::|.:||.|||..|.:.....:||.|:.::||..||.|.||.|||
  Fly   306 GFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPV 370

  Fly   378 LPFLDREYESVEGQPDLSLK-PFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRK 441
            |..|.|     ..|.|.|.: |  .|.:..||.|.||...:|:||:.:..|.:|.||||:.....
  Fly   371 LAHLTR-----MTQTDFSPEDP--KYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIA 428

  Fly   442 NIVAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGI 506
            ...:..:.|||.||.||||.|.||:|:.:||..|::.:.......|...|||..|..:|.|:.||
  Fly   429 ARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGI 493

  Fly   507 HLEI 510
            ||::
  Fly   494 HLKV 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	169/469 (36%)
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	176/487 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461092
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800