DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	171/533 - (32%)
Similarity:	272/533 - (51%)	Gaps:	59/533 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGN---------TKVVFKMENSFGMHL-SE 61
            ||:::  ||.||.|....:..:..:|:.:..|.|:|||         ..|:.||......|. |.
  Fly    10 LFIIL--LVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHTKHTGSP 72

  Fly    62 IYNDPRLKDEAVVGIYSMNKPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVR 126
            :|           |||::......:||.||||.|.||:|:.|.|..:..:...:.:...:|..:|
  Fly    73 VY-----------GIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLR 126

  Fly   127 DAHWKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGE-KNSGSFITEIKEICAQFSTDS 190
            |..||.:|..|||.||..|::.||.|:|...::..:.:|.:.| ....|...|:|:...:|:.|.
  Fly   127 DGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDV 191

  Fly   191 IATIAFGIRANSLENPNAEFRNYGRKMFTFTV-ARAKDFFVAFFLPKLVSLMRIQFFTADFSHFM 254
            |||:||||..||....:.||...|:.|...:. :..|....|.| |:|:.::|||........:.
  Fly   192 IATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALF-PRLMKVLRIQVLDTKNIDYF 255

  Fly   255 RSTIGHVMEERERSGLLRNDLIDVLVSLRKEAAAEPS-----KPHYAK-NQDFLVAQAGVFFTAG 313
            .|.:...|..|:...::|.|:|.:|:..:::..|:.|     :.:|:: ..|.|:||..:||.||
  Fly   256 SSLVTAAMRYRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQCLLFFFAG 320

  Fly   314 FETSSSTMSFALYEMAKHPEMQKRLRDEI---NEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMY 375
            ||..||::.|..:|:..:|.:|.||.:||   :|.|  .|..|:|:|:..::||.|||.|.||.:
  Fly   321 FEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEEL--KGQPLTYDKLTKMKYLDMVVLEALRKW 383

  Fly   376 PVLPFLDREYESVEGQPDLSLKPFYDYTLENGTPVF---------IPIYALHHDPKYWTNPSQFD 431
            |.....|||.     :.|:.|   :|   |||..:|         |||::|||||:.:.:|..|:
  Fly   384 PPSISTDREC-----RQDIDL---FD---ENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFN 437

  Fly   432 PERFSPANRKNIVAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPK 496
            ||||  |:...:.:..|.|||.||.||||:|:.|::.|..:..||.|..:...:.|.:|:..|.:
  Fly   438 PERF--ADGHALESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIR 500

  Fly   497 GFVLQADGGIHLE 509
            |..|:...|..|:
  Fly   501 GHGLKPKNGFWLK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	154/472 (33%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	162/500 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461040
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800