DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp9b1

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	167/532 - (31%)
Similarity:	277/532 - (52%)	Gaps:	49/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLTEVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYND 65
            |...|:..|:....:.|:.|.......::.:.:.:..|.|.:||.......:.||...:||.||
  Fly     1 MSFVEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYN- 64

  Fly    66 PRLKDEAVVGIYSMNKPGLIIRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVRDAHW 130
             |.:...:||::::..|.:.|.|.:|||.|.:|||:.|.|......|: :.|..:.|..:||.||
  Fly    65 -RTRHHKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNIPN-ERLVNDMLNVMRDQHW 127

  Fly   131 KGIRTKLTPVFTSGKVKQMYTLMQE-IGKDLE-LALQRRGEKNSGSFITEIKEICAQFSTDSIAT 193
            :.:|:.|||||||.|::.|:|||.| ..:.|| |...:.......:|..::|.:|.:.|.|.|||
  Fly   128 RNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIAT 192

  Fly   194 IAFGIRANSLENPNAEFRNYGRKMFTFTVARA---KDFFVAFFLPKLVSLMRIQFF-TADFSHFM 254
            .|||::.||.::|..||...|:   |...:|.   ..|.:....||:.:..::..| :.:..:|:
  Fly   193 TAFGLKVNSFDDPENEFHTIGK---TLAFSRGLPFLKFMMCLLAPKVFNFFKLTIFDSTNVEYFV 254

  Fly   255 RSTIGHVMEERERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETSSS 319
            |..: ..|:.||:..:.|.|:|.:|:..:||     ||.::  ..|.:|||..:||.|.||.:|:
  Fly   255 RLVV-DAMQYREKHNITRPDMIQLLMEAKKE-----SKDNW--TDDEIVAQCFIFFFAAFENNSN 311

  Fly   320 TMSFALYEMAKHPEMQKRLRDEI---NEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFL 381
            .:....||:.::.::|:||.:|:   .|||  .|..|:|:..|.:.|:.||:.|.||.:.:....
  Fly   312 LICTTAYELLRNLDIQERLYEEVKETQEAL--KGAPLTYDAAQEMTYMDMVISESLRKWTLSAAA 374

  Fly   382 DREYESVEGQPDLSLKPFYDYTL--ENGTPVF---------IPIYALHHDPKYWTNPSQFDPERF 435
            ||          |..|   ||||  :.||.:|         |||..||.|.:::..|.:||||||
  Fly   375 DR----------LCAK---DYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERF 426

  Fly   436 SPANRKNIVAMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVL 500
            |...:|:::...|.|||.||.:|||:|..::|:|..|.:|:.|:.:.....|.:||....:||.:
  Fly   427 SERRKKDLIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESARGFNI 491

  Fly   501 QADGGIHLEIVN 512
            ....|..:::|:
  Fly   492 IPTTGFWMQLVS 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	155/471 (33%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	155/469 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461044
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800