DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp28a5

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	150/537 - (27%)
Similarity:	253/537 - (47%)	Gaps:	62/537 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLTEVLFV--VVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIY 63
            |||..:..|  ||..|.|:..|   |:.||:::|:|...|..:.||...:|.|:......|.:||
  Fly     1 MVLITLTLVSLVVGLLYAVLVW---NYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIY 62

  Fly    64 NDPRLKDEAVVGIYSMNKPGLIIRDIELIKSILIKDFNRFH-NRYAR-CDPHGDPLGYNNLFFVR 126
            ...:.|.:| |||:....|.|::.:..|.:.:.:.:|..|| |..|: .|...|.:..||.|.:.
  Fly    63 RQYKNKYDA-VGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNIDEKTDFIFANNPFSLT 126

  Fly   127 DAHWKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQ---RRGEKNSGSFITEIKEICAQFST 188
            ...||..|..:||..|.|::|.:|.:..::.:.|...::   |.|.|:.    .:.|.:...|:|
  Fly   127 GEKWKTRRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDG----IDAKHMSLCFTT 187

  Fly   189 DSIATIAFGIRANSLENPNAEFRNYGRKMFT--FTVARAKDFFVAFFL-----PKLVSLMRIQFF 246
            :.:.....|:.|.|..:......:....:|.  :|       ||.||:     |.|..|::::|.
  Fly   188 EMVTDCVLGLGAESFSDKPTPIMSKINDLFNQPWT-------FVLFFILTSSFPSLSHLIKLRFV 245

  Fly   247 TADFSHFMRSTIGHVMEERERSGLL------RNDLIDVLVSLRKEAAAEPSKPHYAKNQD--FLV 303
            ..|...|....:|..:|.| |:.|.      |:|.:|.::.|.::           :|.|  .|:
  Fly   246 PVDVERFFVDLMGSAVETR-RAQLAAGKQFERSDFLDYILQLGEK-----------RNLDNRQLL 298

  Fly   304 AQAGVFFTAGFETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVV 368
            |.:..|...||||:::.::..|..:.::.|.|..||:||...|.:  |::::||:..|.||...|
  Fly   299 AYSMTFLLDGFETTATVLAHILLNLGRNKEAQNLLREEIRSHLQD--GTIAFEKLSDLPYLDACV 361

  Fly   369 DEVLRMYPVLP-FLDREY--ESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQF 430
            .|.:|::|  | |:..:.  ||:|    :..|...::.:|.||.|.:|.|....|.:::.||..|
  Fly   362 QETIRLFP--PGFMSNKLCTESIE----IPNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSF 420

  Fly   431 DPERF-SPANRKNIVAM-AYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKF 493
            .|||| .|...|..... .:..||.||..|||.|...:|.|..:|.|:...:|:..:.|.||..:
  Fly   421 QPERFLEPDAAKTFRERGVFMGFGDGPRVCIGMRFATVQIKAAIVELISKFNVKINDKTRKDNDY 485

  Fly   494 DPKGFVLQADGGIHLEI 510
            :|...:....|||.|::
  Fly   486 EPGQIITGLRGGIWLDL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	130/476 (27%)
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	136/498 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460833
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900