DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	168/520 - (32%)
Similarity:	272/520 - (52%)	Gaps:	47/520 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TEVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRL 68
            |.||..|:  ||.||......|..::::|||...|.|.:|.....:|....|.|...:.|.
  Rat    11 TWVLLAVI--LVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYKGLGRFDMECYKKYG---- 69

  Fly    69 KDEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLGY--NNLFFVRDAHW 130
               .:.|::....|...|.|.|:||::|:|: |:.|.||     ....|:|.  ..:...:|..|
  Rat    70 ---KIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNR-----RDFGPVGIMGKAVSVAKDEEW 126

  Fly   131 KGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIA 195
            |..|..|:|.||||::|:|:.::::.|..|...|::..|  :|..:| :|::...:|.|.|.:.:
  Rat   127 KRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAE--TGKPVT-MKKVFGAYSMDVITSTS 188

  Fly   196 FGIRANSLENPNAEFRNYGRKMFTFTVARAKDFF-------VAF-FLPKLVSLMRIQFFTADFSH 252
            ||:..:||.||...|....:|:..|      |||       |.| ||..:..::.|..|..|...
  Rat   189 FGVNVDSLNNPKDPFVEKTKKLLRF------DFFDPLFLSVVLFPFLTPIYEMLNICMFPKDSIA 247

  Fly   253 FMRSTIGHVMEER-ERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFET 316
            |.:..:..:.|.| :.....|.|.:.::::....:..|.|  |.|.:...::||:.:|..||:||
  Rat   248 FFQKFVHRIKETRLDSKHKHRVDFLQLMLNAHNNSKDEVS--HKALSDVEIIAQSVIFIFAGYET 310

  Fly   317 SSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFL 381
            :|||:||.||.:|.||::||:|::||:.|| ......:|:.:..:|||.||::|.||:||:...|
  Rat   311 TSSTLSFVLYFLATHPDIQKKLQEEIDGAL-PSKAPPTYDIVMEMEYLDMVLNETLRLYPIGNRL 374

  Fly   382 DREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAM 446
            :|..:.     |:.|...:   :..|:.|.||.|||||||::|..|.:|.|||||..|:.:|...
  Rat   375 ERVCKK-----DIELDGLF---IPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDPY 431

  Fly   447 AYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLEIV 511
            .|.|||:||.||||.|..|:..||.|..:|:|.|.:.|:.|...:|...:. :|:.:..|.|:::
  Rat   432 VYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQA-ILEPEKPIVLKVL 495

Fly 512 511
Rat 496 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	150/463 (32%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	149/458 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870