DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6g1 and Cyp3a23-3a1

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	166/521 - (31%)
Similarity:	267/521 - (51%)	Gaps:	51/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TEVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRL 68
            |.||..||  ||.||.:..|.|..::::|||...|.|..|...       ::.|.|.:...:...
  Rat    11 TWVLLAVV--LVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVL-------NYYMGLWKFDVECHK 66

  Fly    69 KDEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLGY--NNLFFVRDAHW 130
            |...:.|::....|...|.|.|:||::|:|: |:.|.||     ....|:|.  ..:...:|..|
  Rat    67 KYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNR-----RDFGPVGIMGKAISVSKDEEW 126

  Fly   131 KGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELAL-QRRGEKNSGSFITEIKEICAQFSTDSIATI 194
            |..|..|:|.||||::|:|:.::::.|..|...| |.:|:.      ..:||:...:|.|.|.:.
  Rat   127 KRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEKGKP------VPVKEVFGAYSMDVITST 185

  Fly   195 AFGIRANSLENPNAEFRNYGRKMFTFTVARAKDFF-------VAF-FLPKLVSLMRIQFFTADFS 251
            :||:..:||.||...|....:|:...      |||       |.| ||..:..::.|..|..|..
  Rat   186 SFGVNVDSLNNPKDPFVEKAKKLLRI------DFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSI 244

  Fly   252 HFMRSTIGHVMEER-ERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFE 315
            .|.:..:..:.|.| :.....|.|.:.::::...::..:.|  |.|.:...:.||:.:|..||:|
  Rat   245 EFFKKFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKES--HTALSDMEITAQSIIFIFAGYE 307

  Fly   316 TSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPF 380
            .:|||:||.|:.:|.||:.||:|::||:.|| ......:|:.:..:|||.||::|.||:||:...
  Rat   308 PTSSTLSFVLHSLATHPDTQKKLQEEIDRAL-PNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNR 371

  Fly   381 LDREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVA 445
            |:|..:.     |:.:...:   :..|:.|.||.||||.||::|..|.:|.|||||..|:.:|..
  Rat   372 LERVCKK-----DVEINGVF---MPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDP 428

  Fly   446 MAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLEI 510
            ..|.|||:||.||||.|..|:..||.|..:|:|.|.:.|:.|...:|...:| :||....|.|::
  Rat   429 YVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQG-LLQPTKPIILKV 492

  Fly   511 V 511
            |
  Rat   493 V 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	147/464 (32%)
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	152/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870