DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	165/517 - (31%)
Similarity:	272/517 - (52%)	Gaps:	40/517 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRLK 69
            |...::|.:||.||.:...:|..:::.|||...|.|.:|......|....|..:..:.|.
  Rat    10 ETWLLLVISLVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAYRKGFWEFDKYCHKKYG----- 69

  Fly    70 DEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLGY--NNLFFVRDAHWK 131
              .:.|:|...:|.|.|.|.::||::|:|: ::.|.||     .:..|:|.  ..:....|..||
  Rat    70 --KLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNR-----RNFGPVGILKKAISISEDEEWK 127

  Fly   132 GIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIAF 196
            .||..|:|.|||||:|:|:.::.:. .|:.:...|:|.:....  |.:|:|...:|.|.|...:|
  Rat   128 RIRALLSPTFTSGKLKEMFPIINQY-TDMLVRNMRQGSEEGKP--TSMKDIFGAYSMDVITATSF 189

  Fly   197 GIRANSLENPNAEFRNYGRKMFTFTVARAKDFFVAF--FLPKLVSLMRIQFFTADFSHFMRSTIG 259
            |:..:||.||...|....:|:..|.:.......|..  ||..|...:.:..|..|...|.::::.
  Rat   190 GVNVDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPLFEALNVSMFPRDVIDFFKTSVE 254

  Fly   260 HV----MEERERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETSSST 320
            .:    |:|:|:.   |.|.:.::::.:.....:   .|.|.:...:|||:.:|..||:||:||.
  Rat   255 RMKENRMKEKEKQ---RMDFLQLMINSQNSKVKD---SHKALSDVEIVAQSVIFIFAGYETTSSA 313

  Fly   321 MSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFLDREY 385
            :||.||.:|.||::||:|:|||:.|| ......:|:.:..:|||.|||:|.||:||:...|:|..
  Rat   314 LSFVLYLLAIHPDIQKKLQDEIDAAL-PNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVC 377

  Fly   386 ESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAMAYQP 450
            ::     |:.:...:   :..||.|.||.:|||.||.||..|.:|.|||||..|:.||....|.|
  Rat   378 KT-----DVEINGVF---IPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLP 434

  Fly   451 FGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLEIVN 512
            ||:||.||||.|..|:..|:.||.:|:|.|.:.|:.|...:|...:| :||.:..:.|::|:
  Rat   435 FGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQG-LLQPEKPLLLKVVS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	148/460 (32%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	155/484 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770