Protein Alignment Cyp6g1 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_610743.2
• Gene: Cyp6g1 / 36316
• FlyBaseID: FBgn0025454
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 131/574 - (22%)
• Similarity: 223/574 - (38%)
• Gaps: 162/574 - (28%)

  Fly     6 VLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRL-K 69
            :|.:::...|.||.     |..|..|.:...|..|          ....|| |:.|:..|..| :
Human    26 ILLLLLIKAVQLYL-----HRQWLLKALQQFPCPP----------SHWLFG-HIQELQQDQELQR 74

  Fly    70 DEAVVGIYSMNKPGLI--------IRDIELIKSILIKDFNRFHNRYARCDPHGDPLGYNNLFFVR 126
            .:..|..:....|..:        :.|.:.:|.||.:...:.|..|....|.   :|| .|..:.
Human    75 IQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPW---IGY-GLLLLN 135

  Fly   127 DAHWKGIRTKLTPVFTSGKVKQMYTLMQE------------IGKD-----------------LEL 162
            ...|...|..|||.|....:|....||.:            :|:|                 ::.
Human   136 GQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKC 200

  Fly   163 ALQRRG----EKNSGSFITEIKEI---------CAQFSTDSIATIA----FGIRANSLENPNAEF 210
            |...:|    ::||.|:|..|.::         .|....|:|.::.    :..||..|.:.:.:
Human   201 AFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTD- 264

  Fly   211 RNYGRKMFTFTVARAKDFFVAFFLPKLVSLMRIQFFTADFSHFMRSTIGHVMEERERSGLLRN-- 273
                                     :::.|.:.|                :.:|.|...:.|.
Human   265 -------------------------QVIQLRKAQ----------------LQKEGELEKIKRKRH 288

  Fly   274 -DLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETSSSTMSFALYEMAKHPEMQKR 337
             |.:|:|:..:.|..:      ...::| |.|:...|...|.:|::|.:|:.||.:|.||:.|:|
Human   289 LDFLDILLLAKMENGS------ILSDKD-LRAEVDTFMFEGHDTTASGISWILYALATHPKHQER 346

  Fly   338 LRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFLDREYESVEGQPDLSLKPFYDY 402
            .|:||: :|:..|.|:::..:..:.|..|.:.|.||:||.:|.:.||..:....||       ..
Human   347 CREEIH-SLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPD-------GR 403

  Fly   403 TLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAMAYQPFGSGPHNCIGSRIGLLQ 467
            :|..|..|.:.||.|||:||.|.||..|||.||:|.:.::  :.|:.||..|..||||.:..:.:
Human   404 SLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQH--SHAFLPFSGGSRNCIGKQFAMNE 466

  Fly   468 SKLGLVSLLKNHSVRNCEATMKDMKF----DP-------KGFVLQADGGIHLEI 510
            .|:.....|              ::|    ||       ...||::..||||.:
Human   467 LKVATALTL--------------LRFELLPDPTRIPIPIARLVLKSKNGIHLRL 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_610743.2	CYP6-like	69..507	CDD:410679	113/505 (22%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	115/507 (23%)