DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6g1 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	522	Identity:	167/522 - (31%)
Similarity:	268/522 - (51%)	Gaps:	51/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TEVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRL 68
            |.||..::  ||.||.:....|..::::|||...|.|.:|.....:|....|.|...|.|.
Mouse    11 TLVLLAII--LVLLYRYGTCTHGLFKKQGIPGPKPLPFLGTVLNYYKGLWKFDMECYEKYG---- 69

  Fly    69 KDEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGD--PLGY--NNLFFVRDA 128
               ...|::....|..:|.|.|.||::|:|: |:.|.||.       |  |:|.  .::...:|.
Mouse    70 ---KTWGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQ-------DFFPVGIMSKSISLAKDE 124

  Fly   129 HWKGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIAT 193
            .||..|..|:|.||||.:|:|:.::::.|..|...|::..||...   ..:|::...:|.|.|.:
Mouse   125 EWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKP---VAVKDVLGAYSMDVIIS 186

  Fly   194 IAFGIRANSLENPNAEFRNYGRKMFTFTVARAKDFF------VAF--FLPKLVSLMRIQFFTADF 250
            ..||:..:||.||...|....:|:..|      |:|      ||.  ||..:..::.|..|..|.
Mouse   187 TTFGVNIDSLNNPEDPFVENAKKVLRF------DYFDPLSLSVALFPFLTPIYEMLNICMFPKDS 245

  Fly   251 SHFMRSTIGHVMEER-ERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGF 314
            ..|.:..:..:.|.| :.....|.|.|.:::....::..:.|  |.|.::..:.||:.:|..||:
Mouse   246 IEFFKKFVDRMTENRLDSKQKHRVDFIYLMMEAYNKSKDKDS--HKALSEIEITAQSIIFIFAGY 308

  Fly   315 ETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLP 379
            ||:||.:||.:|.:|.||::||:|::||:||| ......:|:.:.::|||.||::|.||:||:..
Mouse   309 ETTSSILSFTVYSLATHPDIQKKLQEEIDEAL-PNKAPPTYDTVMAMEYLDMVLNETLRLYPITN 372

  Fly   380 FLDREYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIV 444
            .|.|..:.     |:.:...|   :..|:.|.||.|.|||||::|..|.:|.|||||..|:.:|.
Mouse   373 RLQRVCKK-----DVEINGIY---IPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSID 429

  Fly   445 AMAYQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLE 509
            ...|.|||:||.||||.|..|:..||.|:.:|:|.|.:.|:.|...:|.. :..:||....|.|:
Mouse   430 PYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLKLS-RELLLQPVKPIVLK 493

  Fly   510 IV 511
            :|
Mouse   494 VV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	149/465 (32%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	156/489 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720