DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6g1 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	515	Identity:	165/515 - (32%)
Similarity:	272/515 - (52%)	Gaps:	36/515 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRLK 69
            |...::..:||.||.:...:|..:::.|||...|.|.:|   .:...:..|.    |.......|
Mouse    10 ETWMLLATSLVLLYLYGTHSHGIFKKLGIPGPKPLPFLG---TILAYQKGFW----ECDIQCHKK 67

  Fly    70 DEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLGYNNLFFVRDAHWKGI 133
            ...:.|:|...:|.|.|.|.::||::|:|: ::.|.|| .|..|.|  :....:....:..||.|
Mouse    68 YGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNR-RRFGPVG--ILKKAISISENEEWKRI 129

  Fly   134 RTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIAFGI 198
            |..|:|.||||::|:|:.::.:. .|:.:...|:|......  |.:|:|...:|.|.|...:||:
Mouse   130 RALLSPTFTSGRLKEMFPIINQF-TDVLVRNMRQGLGEGKP--TSMKDIFGAYSMDVITATSFGV 191

  Fly   199 RANSLENPNAEFRNYGRKMFTFTVARAKDFFVAF--FLPKLVSLMRIQFFTADFSHFMRSTIGHV 261
            ..:||.||...|....:|:..|.:.......|..  ||..:...:.:..|..|...|..:::..:
Mouse   192 NIDSLNNPQDPFVEKIKKLLKFDIFDPLFLSVTLFPFLTPVFDALNVSLFPRDVISFFTTSVERM 256

  Fly   262 ----MEERERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETSSSTMS 322
                |:|:|:.   |.|.:.::::.:.....|   .|.|.:...:|||:.:|..||:||:||.:|
Mouse   257 KENRMKEKEKQ---RVDFLQLMINSQNYKTKE---SHKALSDVEIVAQSVIFIFAGYETTSSALS 315

  Fly   323 FALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFLDREYES 387
            ||||.:|.||::||:|:|||:.|| ......:|:.:..:|||.|||:|.||:||:...|:|..::
Mouse   316 FALYLLAIHPDVQKKLQDEIDAAL-PNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKT 379

  Fly   388 VEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAMAYQPFG 452
                 |:.:...:   :..||.|.||.:|||.|||||..|.:|.|||||..|:.:|....|.|||
Mouse   380 -----DVEINGLF---IPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYLPFG 436

  Fly   453 SGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLEIVN 512
            |||.||||.|..|:..|:.||.:|:|.:|:.|:.|...:|...:| :||.:..:.|::|:
Mouse   437 SGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIPLKLSKQG-LLQPENPLLLKVVS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	150/458 (33%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	155/480 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710