DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6g1 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	519	Identity:	169/519 - (32%)
Similarity:	276/519 - (53%)	Gaps:	45/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRLK 69
            |...::..:||.||.:..|.|..::::|||...|.|.:|.....:|....|.|...:.|.
Mouse    10 ETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYKGLWKFDMECYKKYG----- 69

  Fly    70 DEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLGYNN--LFFVRDAHWK 131
              ...|::....|.|.:.|.|.||::|:|: |:.|.||     ....|:|..:  :...:|..||
Mouse    70 --KTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNR-----RDFGPVGIMSKAISISKDDEWK 127

  Fly   132 GIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIAF 196
            ..|..|:|.|||||:|:|:.::::.|..|...|:::.:|  |..:| :|::...:|.|.|.:.:|
Mouse   128 RYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKK--GKPVT-MKDVLGAYSMDVITSTSF 189

  Fly   197 GIRANSLENPNAEFRNYGRKMFTFTVARAKDFF-------VAF-FLPKLVSLMRIQFFTADFSHF 253
            |:..:||.||...|....:|:..|      |||       |.| ||..:..::.|..|..|...|
Mouse   190 GVNVDSLNNPEDPFVEKAKKLLRF------DFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEF 248

  Fly   254 MRSTIGHVMEER-ERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETS 317
            .:..:..:.|.| :.....|.|.:.::::....:..:.|  |.|.:...:.||:.:|..||:||:
Mouse   249 FKKFVDRMKESRLDSKQKHRVDFLQLMMNSHNNSKDKVS--HKALSDMEITAQSIIFIFAGYETT 311

  Fly   318 SSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFLD 382
            |||:||.|:.:|.||::||:|:|||:||| ......:|:.:..:|||.||::|.||:||:...|:
Mouse   312 SSTLSFTLHSLATHPDIQKKLQDEIDEAL-PNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLE 375

  Fly   383 REYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAMA 447
            |..:.     |:.|...|   :..|:.|.||.|||||||::|:.|.:|.|||||..|:.:|....
Mouse   376 RVCKK-----DVELNGVY---IPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYV 432

  Fly   448 YQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLEIV 511
            |.|||:||.||:|.|..|:..||.|..:::|.|.:.|:.|...:|...:| :||.:..|.|::|
Mouse   433 YLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQG-LLQPEKPIVLKVV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	152/463 (33%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	159/487 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720